Abstract
The presence of acetylcholine (ACh) (16), choline acetyltransferase (CAT) (6), the histochemical visualization of acetyl-cholinesterase-rich fibers (17), and the output of ACh from the cortical surface, demonstrate the existence of a dense cholinergic network in the cerebral cortex of all animal species so far investigated. However, the origin of this cortical cholinergic network is still mostly unknown. According to McGeer (10), it could be partly formed by intrinsic cholinergic neurons. The destruction of the septum in the rat is followed by approximately 40% decrease in ACh content of (15) and by a similar decrease in spontaneous ACh output from the cerebral cortex (1). These findings suggest that part of the cortical cholinergic network is formed by fibers originating from or passing through the septum.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Casamenti, F., Pedata, F., Corradetti, R. and Pepeu, G. (1980): Neuropharmacology 19:597–605.
Emson, P.C. and Lindvall, O. (1979): Neuroscience 4:1–30.
Fonnum, F. (1975): J. Neurochem. 24:407–409.
Kelly, P.H. and Moore, K.E. (1978): Exp. Neurol. 61:479–484.
Koenig, J.F. and Klippel, R. (1963): The Rat Brain; A Stereotaxic Atlas, William and Wilkins, Baltimore.
Kuhar, M.J. (1976): In Biology of Cholinergic Function (eds) A.M. Goldberg and I. Hanin, Raven Press, New York, pp. 3–27.
Kuhar, M.J. (1977): In Cholinergic Mechanisms and Psycho-pharmacology (ed) D.J. Jenden, Plenum Press, New York, pp. 447–456.
Kuhar, M.J., Sethy, V.H., Roth, R.H. and Aghajaniaanian G.K. (1973): J. Neurochem. 20:581–593.
Lowry, O.M., Rosebrough, N.J., Farr, A.L. and Randall, R.J. (1951): Biol. Chem. 193:265–275.
McGeer, P.L. and McGeer, E.G. (1979): In Nutrition and the Brain, Vol. 5 (eds) A. Barbeau, J.H. Growden and R. J. Wurtman, Raven Press, New York, pp. 177–199.
Mesulam, M.M. and Van Hoesen, G.W. (1976): Brain Res. 109: 152–157.
Mulas, A., Mulas, M.L. and Pepeu, G. (1974): Psychopharmacology (Berl.) 30:223–230.
Nistri, A., Bartolini, A., Deffenu, G. and Pepeu, G. (1972): Neuropharmacology 11:665–679.
Pepeu, G. (1973): Prog. Neurobiol. 2:257–288.
Pepeu, G., Mulas, A., Mulas, M.L. (1973): Brain Res, 57:153–164.
Saèlens, J.K. and Simke, J.P. (1976): In Biology of Cholinergic Function (eds) A.M. Goldberg and I. Hanin, Raven Press, New York, pp. 661–706.
Silver, A. (1974): The Biology of Cholinesterases, North Holland Publishing Company, Amsterdam.
Simon, J.R., Atweh, S. and Kuhar, M.J. (1976): J. Neurochem. 26:909–922.
Simon, J.R. and Kuhar, M.J. (1976): J. Neurochem. 27:93–99.
Tucek, S. (1978): Acetylcholine Synthesis in Neurons, Chapman and Hall, London.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Plenum Press, New York
About this chapter
Cite this chapter
Casamenti, F., Pedata, F., Sorbi, S., Conte, G.L., Pepeu, F. (1981). Lesions of the Globus Pallidus: Changes in Cortical Choline Acetyltransferase, Choline Uptake and Acetylcholine Output in the Rat. In: Pepeu, G., Ladinsky, H. (eds) Cholinergic Mechanisms. Advances in Behavioral Biology, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8643-8_69
Download citation
DOI: https://doi.org/10.1007/978-1-4684-8643-8_69
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-8645-2
Online ISBN: 978-1-4684-8643-8
eBook Packages: Springer Book Archive