Newly Synthesized Acetylcholine Receptor in Denervated Skeletal Muscle
It is well known that the acetylcholine receptor (AChR) remains only in the neuromuscular junction, very soon after its formation in the chick embryo between the 12th and 14th incubation day (1,4), following its gradual disappearance from the entire length of the skeletal muscle fiber. Whatever the causes of this disappearance of extrajunctional AChR may be, it is also well known that when the muscle fiber is denervated (2,3,5) the extrajunctional AChR is then formed ex novo and reappears throughout the entire sarcolemma. We therefore looked to see where this resynthesis takes place in the denervated fiber.
KeywordsAcetylcholine Receptor Chick Embryo Neuromuscular Junction Skeletal Muscle Fiber Control Muscle
Unable to display preview. Download preview PDF.