Regulation of Muscarinic Receptor Binding

  • F. J. Ehlert
  • W. R. Roeske
  • H. I. Yamamura
Part of the Advances in Behavioral Biology book series (ABBI, volume 25)


The specific binding of [3H] antagonists to muscarinic receptors from neuronal tissue has been demonstrated by several investigators (6,19,24,28,32,37). In each case, the binding of [3H] antagonists is consistent with the law of mass action for a single class of independent receptors. Similarly, the results of antagonist/ [3H] antagonist competition experiments are also consistent with the law of mass action (23). Perhaps the most convincing evidence demonstrating that the binding of [3H] antagonists represents a specific interaction with the muscarinic receptor is the excellent quantitative agreement between the values of dissociation constants determined by binding experiments and by antagonism of agonist induced contractions of the guinea pig ileum (8,10).


Muscarinic Receptor Guanine Nucleotide Muscarinic Agonist Agonist Binding High Affinity Site 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • F. J. Ehlert
    • 1
  • W. R. Roeske
    • 1
  • H. I. Yamamura
    • 1
  1. 1.Departments of Pharmacology, Psychiatry and Internal MedicineUniversity of Arizona Health Sciences CenterTucsonUSA

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