Investigation on the Effect of Cholinergic Agonists and Antagonists on Cyclic Nucleotide Levels invivo: Effect of Lyso-Phosphatidylserine

  • S. Teolato
  • G. Calderini
  • A. C. Bonetti
  • A. Battistella
  • G. Toffano
Part of the Advances in Behavioral Biology book series (ABBI, volume 25)


Muscarinic receptor stimulation has been shown to increase cGMP levels in nervous tissue, both in vivo (25) and in vitro (1,11,18), suggesting that such a nucleotide, by analogy with the role postulated for cAMP, mediates the muscarinic actions of acetylcholine (ACh) (5,21). Moreover, it has been proposed (14,15) that cGMP and cAMP, by acting in opposite direction, provide the mechanism for bi-directional control of intracellular processes.


Cyclic Nucleotide Guanylate Cyclase Anticholinergic Drug Septal Lesion cGMP Level 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • S. Teolato
    • 1
  • G. Calderini
    • 1
  • A. C. Bonetti
    • 1
  • A. Battistella
    • 1
  • G. Toffano
    • 1
  1. 1.Fidia Research LaboratoriesAbano TermeItaly

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