On the Ionic Mechanism of Presynaptic Muscarinic Receptor Action in Rat Hippocampus

  • O. Nordstrom
  • A. Westlind
  • B. Hedlund
  • A. Unden
  • T. Bartfai
Part of the Advances in Behavioral Biology book series (ABBI, volume 25)


Occupancy of the muscarinic acetylcholine receptor (mAChR) with an agonist may trigger a number of different responses dependent on the localization of the receptor. The mAChR mediates depolarizing actions in Renshaw cells (10–12), in sympathetic ganglion (13) and hyperpolarizing actions in the heart (21). It activates synthesis of cGMP in a number of tissues (1) and inhibits the β-receptor activated adenylate cyclase in heart (25). Some of these actions take place on the presynaptic side and some on the postsynaptic side of the synapse.


Muscarinic Receptor Hippocampal Slice Ionic Mechanism Muscarinic Acetylcholine Receptor Muscarinic Agonist 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • O. Nordstrom
    • 1
  • A. Westlind
    • 1
  • B. Hedlund
    • 1
  • A. Unden
    • 1
  • T. Bartfai
    • 1
  1. 1.Department of BiochemistryArrhenius LaboratoryStockholmSweden

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