Biochemical and Pupillographic Studies of Guinea Pig Iris During Acetylcholinesterase Inhibition

  • F. Fonnum
  • N. E. Søli
  • P. K. Opstad
  • M. Opsahl
  • R. Lund-Karlsen
Part of the Advances in Behavioral Biology book series (ABBI, volume 25)


The effect of cholinergic drugs on the iris function is well known. Acetylcholinesterase (AChE) inhibitors such as soman leads to miosis, and atropine-like compounds give myadriasis. In the present communication we describe the miotic effect of single and multiple doses of soman to the eye. It will be show that transmitters other than acetylcholine (ACh) must be involved in the fine regulation of the pupillary function.


Muscarinic Receptor AChE Activity Pupillary Diameter Superior Cervical Ganglion AChE Inhibition 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • F. Fonnum
    • 1
  • N. E. Søli
    • 1
  • P. K. Opstad
    • 1
  • M. Opsahl
    • 1
  • R. Lund-Karlsen
    • 1
  1. 1.Division for ToxicologyNorwegian Defence Research EstablishmentKjellerNorway

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