Biochemical and Pupillographic Studies of Guinea Pig Iris During Acetylcholinesterase Inhibition

  • F. Fonnum
  • N. E. Søli
  • P. K. Opstad
  • M. Opsahl
  • R. Lund-Karlsen
Part of the Advances in Behavioral Biology book series (ABBI, volume 25)


The effect of cholinergic drugs on the iris function is well known. Acetylcholinesterase (AChE) inhibitors such as soman leads to miosis, and atropine-like compounds give myadriasis. In the present communication we describe the miotic effect of single and multiple doses of soman to the eye. It will be show that transmitters other than acetylcholine (ACh) must be involved in the fine regulation of the pupillary function.


Muscarinic Receptor AChE Activity Pupillary Diameter Superior Cervical Ganglion AChE Inhibition 


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  1. 1.
    Barstad, J.A.B. (1960): Arch. Int. Pharmacodyn. 128:143–168.Google Scholar
  2. 2.
    Bito, L.Z. and Banks, N. (1969): Arch. Ophthal. 82:681–686.CrossRefGoogle Scholar
  3. 3.
    De Prada, M. and Zur Gher, G. (1976): Life Sci. 19:1161–1174.CrossRefGoogle Scholar
  4. 4.
    Ehinger, B. and Falck, B. (1966): Acta Physiol. Scand. 67:201–209.CrossRefGoogle Scholar
  5. 5.
    Harris, L.S., Shimmoy, M. and Mittag, T.W (1973): Arch. Ophthal. 89:49–51.CrossRefGoogle Scholar
  6. 6.
    Kloog, Y., Sachs, D.I. Korczyn, A.D., Heron, D.S. and Sokolovsky, M. (1979): Biochem. Pharmacol. 28:1505–1512.CrossRefGoogle Scholar
  7. 7.
    Lund-Karlsen, R. (1978): Exp. Eye Res. 27:577–581.CrossRefGoogle Scholar
  8. 8.
    Lund-Karlsen, R. and Fonnum, F. (1977): J. Neurochem. 29: 577–581.Google Scholar
  9. 9.
    Lund-Karlsen, R. and Soli, N. (1979): Acta Opthal. 57:41–47CrossRefGoogle Scholar
  10. 10.
    Malmfors, T. (1965): Acta Physiol. Scand. 64:377–382.CrossRefGoogle Scholar
  11. 11.
    Malmfors, T. (1967): Circ. Res. 20 & 21(Suppl.3):25–42.Google Scholar
  12. 12.
    Mittag, T.W., Ehrenprise, S. and Hehir, R.M. (1971): Biochem. Pharmacol. 20:2263–2273.CrossRefGoogle Scholar
  13. 13.
    Sachs, D.I., Kloog, Y., Korezyn, A.D., Heron, D.S. and Sokolovsky, M. (1979): Biochem. Pharmacol. 28:1513–1518.CrossRefGoogle Scholar
  14. 14.
    Sim, V.M. (1975): IN Cholinergic Mechanisms (ed) P.G. Waser, Raven Press, New York, pp. 395–398.Google Scholar
  15. 15.
    Søli, N.E., Lund-Karlsen, R., Opsahl, M. and Fonnum, F. (1980): J. Neurochem. 35:723–728.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • F. Fonnum
    • 1
  • N. E. Søli
    • 1
  • P. K. Opstad
    • 1
  • M. Opsahl
    • 1
  • R. Lund-Karlsen
    • 1
  1. 1.Division for ToxicologyNorwegian Defence Research EstablishmentKjellerNorway

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