Interrelationship between Acetylcholine Release from Synaptosomes and Na-K ATPase Activity

  • J. R. Cooper
  • E. M. Meyer
Part of the Advances in Behavioral Biology book series (ABBI, volume 25)


Since the mechanism of neurotransmitter release remains unclear, we have recently considered the possibility that the terminal membrane bound Na-K ATPase is involved with this process (17). Specific inhibitors of this enzyme, such as the cardiac glycoside ouabain release neuronal acetylcholine (ACh)(19,27) and catecholamines (12,22), even in the absence of extracellular calcium. These observations suggest that Na-K ATPase inhibition might bypass a calcium dependent step in neurotransmitter release. Since calcium ions also inhibit this enzyme (21), we have proposed that treatments which promote calcium influx indirectly inhibit Na-K ATPase activity and increase neurotransmitter efflux in a manner similar to that seen with ouabain in calcium-free media.


Neurotransmitter Release Electrical Field Stimulation Field Stimulation Krebs Ringer Buffer Krebs Ringer 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • J. R. Cooper
    • 1
  • E. M. Meyer
    • 1
  1. 1.Department of PharmacologySchool of Medicine Yale UniversityNew HavenUSA

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