Least Squares Analyses of the Kinetics of Choline Uptake in Rat Brain Synaptosomes

  • A. M. Kotas
  • A. K. Prince
Part of the Advances in Behavioral Biology book series (ABBI, volume 25)


One assumption implicit to least squares analyses is that any variation in the error of the dependent variable is known, so that the correct weighting can be applied (3). However, there has been no discussion of the errors associated with measurements of choline (Ch) uptake. Cleland (2) defined weights for two different distributions, in which errors were either constant (homoscedastic) or proportional to velocity (heteroscedastic).


Weighting Scheme Constant Error Choline Uptake Mean Square Correct Weighting 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • A. M. Kotas
    • 1
  • A. K. Prince
    • 1
  1. 1.University of London, King’s College The StrandLondonEngland

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