The Uptake and Acetylation of 3H-Choline in Brain of Inbred Strains of Mice
In a study of inbred strains of mice it was reported that whole brain ChAT activities varied in the following order: Balb/c > DBA/2 > C57B1/6 (6). ChAT activities in both the temporal and frontal cortex of the DBA/2 strain of mice were reported to be greater than in the C57B1/6 strain (5). It was suggested that these differences may be correlated with differences in learning ability. The in vivo turnover rates of acetylcholine (ACh) in frontal-parietal cortex of these strains were in agreement with ChAT activities in this order (2). Thus greater ChAT activity may be necessary where turnover rate is greatest.
KeywordsFrontal Cortex Turnover Rate Inbred Strain Steady State Concentration ChAT Activity
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