Origin of Acetyl Groups of Acetylcholine in the Brain and the Role of Acetylcoenzyme A in the Control of its Synthesis

  • S. Tucek
  • V. Dolezal
  • J. Ricny
Part of the Advances in Behavioral Biology book series (ABBI, volume 25)


Problems concerning the origin of acetyl groups of acetylcholine (ACh) in the brain have been reviewed recently (19,27). It is the prevailing view that the acetylcoenzyme A (acetylCoA) used for the synthesis of ACh in the brain is derived from pyruvate 12,16,28,29) and is formed by pyruvate dehydrogenase, which is localized in the mitochondrial matrix. The suggestion that there is extramitochondrial pyruvate dehydrogenase present in the brain (11) is not supported by observations made on subcellular fractions of brain homogenates (25).


Incubation Medium Caudate Nucleus Pyruvate Dehydrogenase Cholinergic Neuron Choline Acetyltransferase 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • S. Tucek
    • 1
  • V. Dolezal
    • 1
  • J. Ricny
    • 1
  1. 1.Institute of PhysiologyCzechoslovak Academy of SciencePragueCzechoslovakia

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