Advertisement

Synthesis of Choline in the Brain

  • H. Kewitz
  • O. Pleul
Part of the Advances in Behavioral Biology book series (ABBI, volume 25)

Abstract

Specific radioactivities of choline (Ch), phosphorylcholine (PCh), lecithin, lysolecithin and glycerylphosphorylcholine (GPCH) have been measured in blood, liver, muscle, and including acetylcholine (ACh) in brain after injection (i.v) of three labelled precursors, Ch, the methyl group of methionine and ethanolamine. In relation to the specific activity of Ch in blood there was significantly more radioactivity in the Ch of brain after labelled methyl groups and labelled ethanolamine than after labelled Ch.

Keywords

Turnover Rate Pool Size Specific Radioactivity Venous Blood Flow Arterial Blood Supply 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Aquilonius, S.-M., Coder, G., Lying-Tunell, U., Malmlund, H.D. and Schubert, J.(1975): Brain Res. 99:430–433.CrossRefGoogle Scholar
  2. 2.
    Blusztajn, J.K., Zeisel, S.H. and Wurtman, R.J. (1979): Brain Res. 179:319–327.CrossRefGoogle Scholar
  3. 3.
    Dross, K. and Kewitz, H. (1966): N.-S. Arch. Pharmakol. 255: 10.CrossRefGoogle Scholar
  4. 4.
    Dross, K. and Kewitz, H. (1972): N.-S. Arch. Pharmakol. 274: 91–106.CrossRefGoogle Scholar
  5. 5.
    Freeman, J.J., Choi, R.L. and Jenden, D.J. (1975): J. Neurochem. 24:729–734.Google Scholar
  6. 6.
    Illingworth, D.R. and Portman, O.W. (1972): Biochem. J. 557: 557–567.Google Scholar
  7. 7.
    Kewitz, H. and Pleul, O. (1977): Proc. Nat. Acad. Sci. 72: 2181–2185.Google Scholar
  8. 8.
    Mozzi, R. and Porcellati, G. (1979): FEBS Lett. 100:363–366.CrossRefGoogle Scholar
  9. 9.
    Nordberg, A. (1977): Acta Physiol. Scand. Suppl. 445.Google Scholar
  10. 10.
    Saito, M. and Kanfer, J. (1973): Biochem. Biophys. Res. Comm. 53: 391–398.CrossRefGoogle Scholar
  11. 11.
    Spanner, S., Hall, R.C. and Ansell, G.B. (1976): Biochem. J. 154:133–140.Google Scholar
  12. 12.
    Tucek, S. (1978): Acetylcholine Synthesis in Neurons, Chapman and Hall, London.Google Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • H. Kewitz
    • 1
  • O. Pleul
    • 1
  1. 1.Department of Clinical PharmacologyFree University of BerlinBerlin 45West Germany

Personalised recommendations