A Vesicular Site of Origin for the Release of a Cholinergic False Transmitter at the Torpedo Synapse
The morphological studies of Ceccarelli, Heuser (2,6) and others (for review see 14) have shown convincingly the increased occurrence of exocytotic profiles (of vesicles fusing with the presynaptic membrane) during induced activity at the neuromuscular function. Vesicle recycling is apparent from the inclusion of extracellular markers, observed in a number of tissues (5,11,15), but this does not necessarily prove that transmitter-containing vesicles undergo a similar process. Similarly, biochemical studies involving a comparison of the degree of radiolabelling of acetylcholine (ACh) in subcellular pools with that of stimulus-released transmitter, has also been subject to major difficulties of interpretation.
KeywordsElectric Organ High Frequency Stimulation Acetate Ester Vesicle Recycling Vesicle Population
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