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Early Effects of Denervation on Acetylcholine and Choline Acetyltransferase in Skeletal Muscle

  • R. Miledi
  • P. C. Molenaar
  • R. L. Polak
Part of the Advances in Behavioral Biology book series (ABBI, volume 25)

Abstract

The effects of motor nerve section on the physiology and ultrastructure of nerve and muscle have been studied in great detail (see for instance 2,18,27). After a delay which is dependent on the length of the nerve stump, the transmission of impulses fails, due to disintegration of motor nerve terminals. At this time motor axons still conduct impulses but they also degenerate later after denervation. In the frog the muscle membrane at the junctions is not left naked because Schwann cells take the place previously occupied by the motor terminals. In the rat this occurs only transiently.

Keywords

Sciatic Nerve Schwann Cell Frog Muscle Denervated Muscle Motor Nerve Terminal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • R. Miledi
    • 1
  • P. C. Molenaar
    • 2
  • R. L. Polak
    • 3
  1. 1.Department of BiophysicsUniversity College LondonLondonEngland
  2. 2.Department of Pharmacology, Sylvius LaboratoriesLeiden University Medical CenterLeidenThe Netherlands
  3. 3.Medical Biological Laboratory TNORijswijkThe Netherlands

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