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Na+−K+-Activated ATPase and Non-Quantal/Cytoplasmic Release of Acetylcholine

  • Chapter
Cholinergic Mechanisms

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 25))

Abstract

Essentially there are two hypotheses which attempt to explain how transmitters are released from axon terminals (cf. 14,16,20). Exocytosis assumes that transmitters are packed in vesicles which, after having fused with the membrane of the axon terminal, discharge their contents into the external cleft. The first observation of the location of a transmitter in vesicles at nerve endings dates back to 1952; Blaschko and Welch for noradrenaline (7) and Fatt and Katz for acetylcholine (ACh) (16). Another hypothesis is that the transmitter is released from the cytoplasm (7,13,27,28,38,39). However, none of them can explain how transmitters cross the membrane and what kind of membrane mechanism operates to make the membrane permeable to the transmitters.

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Author information

Authors and Affiliations

  1. Department of Pharmacology, Semmelweis University of Medicine, Budapest, Hungary

    E. S. Vizi

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  1. E. S. Vizi
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Editors and Affiliations

  1. Institute of Pharmacology, University of Florence, Florence, Italy

    Giancarlo Pepeu

  2. Mario Negri Institute for Pharmacological Research, Milan, Italy

    Herbert Ladinsky

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© 1981 Plenum Press, New York

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Vizi, E.S. (1981). Na+−K+-Activated ATPase and Non-Quantal/Cytoplasmic Release of Acetylcholine. In: Pepeu, G., Ladinsky, H. (eds) Cholinergic Mechanisms. Advances in Behavioral Biology, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8643-8_18

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  • DOI: https://doi.org/10.1007/978-1-4684-8643-8_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8645-2

  • Online ISBN: 978-1-4684-8643-8

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