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Na+−K+-Activated ATPase and Non-Quantal/Cytoplasmic Release of Acetylcholine

  • E. S. Vizi
Part of the Advances in Behavioral Biology book series (ABBI, volume 25)

Abstract

Essentially there are two hypotheses which attempt to explain how transmitters are released from axon terminals (cf. 14,16,20). Exocytosis assumes that transmitters are packed in vesicles which, after having fused with the membrane of the axon terminal, discharge their contents into the external cleft. The first observation of the location of a transmitter in vesicles at nerve endings dates back to 1952; Blaschko and Welch for noradrenaline (7) and Fatt and Katz for acetylcholine (ACh) (16). Another hypothesis is that the transmitter is released from the cytoplasm (7,13,27,28,38,39). However, none of them can explain how transmitters cross the membrane and what kind of membrane mechanism operates to make the membrane permeable to the transmitters.

Keywords

Neuromuscular Junction Axon Terminal Transmitter Release Total Release Mepp Amplitude 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • E. S. Vizi
    • 1
  1. 1.Department of PharmacologySemmelweis University of MedicineBudapestHungary

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