Regulation of Acetylcholine Synthesis and Release in the Isolated Heart

  • K. Loffelholz
  • R. Lindmar
  • W. Weide
Part of the Advances in Behavioral Biology book series (ABBI, volume 25)


In the two decades following Loewi’s work (8,9) on the frog heart several research groups tried to use the isolated heart preparation from higher vertebrates for further investigations on synthesis, release and inactivation of acetylcholine (ACh). However the results were discouraging because the overflow of ACh during vagal stimulation was near, or below, the limit of the assay.


Nerve Stimulation Vagal Stimulation Cholinesterase Activity Lower Diagram Frog Heart 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    DeSantis, V.P., Langsfeld, W., Lindmar, R. and Loffelholz, K. (1975): Brit. J. Pharmacol. 55:343–350.CrossRefGoogle Scholar
  2. 2.
    Dieterich, H.A., Kaffei, H., Kilbinger, H. and Loffelholz, K.(1976): J. Pharmacol. Exp. Ther. 199:236–246.Google Scholar
  3. 3.
    Dieterich, H.A., Lindmar, R. and Loffelholz, K. (1978): N.-S. Arch. Pharmacol. 301:207–215.CrossRefGoogle Scholar
  4. 4.
    Haga, T. and Noda, H. (1973): Biochim. Biophys, Acta 291: 564–575.CrossRefGoogle Scholar
  5. 5.
    Goldberg, A.M. and McCaman, R.E. (1974): IN Choline and Acetyl choline. Handbook of Chemical Assay Methods, (ed) I. Hanin, Raven Press, New York, pp. 47–61.Google Scholar
  6. 6.
    Kilbinger, H. and Loffelholz, K. (1976): J. Neur. Trans. 38:9–14.CrossRefGoogle Scholar
  7. 7.
    Lindmar, R., Loffelholz, K. and Weide, W. (1979): J. Pharmacol. Exp. Ther. 210:166–173.Google Scholar
  8. 8.
    Loewi, O. (1921): Pflug. Arch. Ges. Physiol. 189:239–242.CrossRefGoogle Scholar
  9. 9.
    Loewi, O. and Navratil, E. (1926): Pflug. Arch. Ges. Physiol. 208:689–696.CrossRefGoogle Scholar
  10. 10.
    Macintosh, F.C. and Collier, B. (1976): IN Neuromuscular Junction. Handbook of Experimental Pharmacology, (ed) E. Zaimis, Springer-Verlag, New York, pp. 99–228.Google Scholar
  11. 11.
    Szerb, J.C. and Somogyi, G.T. (1973): Nature New Biology 241:121–122.Google Scholar
  12. 12.
    Vaca, K. and Pilar, G. (1979): J. Gen. Physiol. 72:605–628CrossRefGoogle Scholar
  13. 13.
    Yamamura, H.I. and Snyder, S.H. (1973): J. Neurochem. 21:1355–1374.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • K. Loffelholz
    • 1
  • R. Lindmar
    • 1
  • W. Weide
    • 1
  1. 1.Department of PharmacologyUniversity of MainzMainzFederal Republic of Germany

Personalised recommendations