Abstract
The venom of the black widow spider (BWSV), Latrodectus mactans tredecimguttatus, contains a neurotoxin causing a massive transmitter release from various vertebrate terminals (3,6,9,13). The pharmacological and physiological effects of this venom, in vivo and in vitro, are well known (1,7,15). On the other hand, its mechanism of action is still not clear, despite the fact that much evidence on the mode of action of this venom at vertebrate neuromuscular junctions has been collected in recent years (5). Some insight into this problem was furnished by previous investigations on the rat sympathetic ganglion (13,14).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Conti-Tronconi, B., Gotti, C., Paggi, P. and Rossi, A. (1979) Brit. J. Pharmacol. 66:33–38.
Clark, A.W., Hurlbut, W.P. and Mauro, A. (1972): J. Cell Biol. 52:1–14.
Frontali, N. (1972): Brain Res. 37:146–148.
Gorio, A., Hurlbut, W.P. and Ceccarelli, B. (1978): J. Cell. Biol. 78:716–733.
Gorio, A., Rubin, L.L. and Mauro, A. (1978): J. Neurocytol. 7:193–205.
Granata, F., Paggi, P. and Frontali, N. (1972): Toxicon 10:551–555.
Grasso, A., Alema, S., Rufini, S. and Senni, M.I. (1980): Nature 283:774–776.
Hess, A. (1965): J. Cell Biol. 25:1–19.
Longenecker, H.E. Jr., Hurlbut, W.P., Mauro, A. and Clark, A.W. (1970): Nature 225:701–703.
Martin, A.R. and Pilar, G. (1963): J. Physiol. 168:464–475.
Marwitt, R., Pilar, G. and Weakly, J.N. (1971): Brain Res. 25:317–334.
Mayer, O. and Michalek, H. (1971): Biochem. Pharmacol. 20:3029–3037.
Paggi, P. and Rossi, A. (1971): Toxicon 9:265–269.
Paggi, P. and Toschi, G. (1972): Life Sci. 11:413–417.
Sampayo, R.R.L. (1944): J. Pharmacol. Exp. Ther. 80:309–322.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Plenum Press, New York
About this chapter
Cite this chapter
Bolzoni, L., Meneguz, A., Paggi, P. (1981). Effect of Latrodectus Mactans Tredecimguttatus Venom on Synaptic Transmission of Chicken Ciliary Ganglion in Vitro . In: Pepeu, G., Ladinsky, H. (eds) Cholinergic Mechanisms. Advances in Behavioral Biology, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8643-8_14
Download citation
DOI: https://doi.org/10.1007/978-1-4684-8643-8_14
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-8645-2
Online ISBN: 978-1-4684-8643-8
eBook Packages: Springer Book Archive