Lateral Diffusion as a Rate-Limiting Step in Mitochondrial Electron Transport

  • Brad Chazotte
  • Charles R. Hackenbrock


The effects of membrane protein density, temperature, and aqueous sucrose concentration on the maximum rate of mitochondrial electron transport and diffusion rates of redox components are examined. It is shown that these factors affect both the rate of lateral diffusion and the rate of electron transport. These effects are discussed in relation to the random collision model of mitochondrial electron transport. The results show that mitochondrial electron transport is a multicollision,obstructed, long-range, diffusional process and that the maximum rate of mitochondrial electron transport in the ubiquinone region is limited by diffusion.


Electron Transport Lateral Diffusion Protein Density Electron Transport Activity Redox Partner 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Brad Chazotte
    • 1
  • Charles R. Hackenbrock
    • 1
  1. 1.Laboratories for Cell Biology Department of Anatomy, School of MedicineUniversity of North Carolina at Chapel HillChapel HillUSA

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