Studies of the Secretion and the Metabolism of Steroid Conjugates: Synthesis, Analysis, and Use of Doubly Labeled Compounds

  • E. E. Baulieu
  • R. Emiliozzi
  • M. C. Lebeau
  • C. Corpéchot
  • P. Robel


The conjugated steroids, namely, the hemi-esters of sulfuric acid (sulfates, S) and the β-D-glucopyranuronosides (glucuronides, G) were considered as detoxication forms of the hormones and their metabolites. Recently, the adrenal cortical secretion of dehydroisoandrosterone sulfate (DS) [1] and the metabolic transformation of this compound into other compounds and especially other steroid conjugates were shown, and renewed the interest in their study [2,3]. Some problems concerning the synthesis and analysis of steroid conjugates and the application of the methods so described to biochemical research will be considered.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Baulieu, E.E., Compt. Rend. Acad. Sci. 251: 1421 (1960).Google Scholar
  2. 2.
    Roberts, K.D., Van de Wiele, R.L., and Lieberman, S., J. Biol. Chem. 236: 2213 (1961).PubMedPubMedCentralGoogle Scholar
  3. 3.
    Baulieu, E.E., Corpéchot, C., Dray, F., Emiliozzi, R.,Lebeau, M.C., Mauvais-Jarvis, P., and Robel, P., in Pincus, G. (editor), Recent Progress in Hormone Research 21:411 (1965).Google Scholar
  4. 4.
    Sobel, A.E., and Sperri, P.E., J. Am. Chem. Soc. 64: 361 (1942).CrossRefGoogle Scholar
  5. 5.
    Baulieu, E.E., and Emiliozzi, R., Bull. Soc. Chim. Biol. 44: 823 (1962).Google Scholar
  6. 6.
    Baulieu, E.E., Corpéchot, C., and Emiliozzi, R., Steroids 2: 429 (1963).CrossRefGoogle Scholar
  7. 7.
    Goebel, W.F., and Sabers, F.H., J. Biol. Chem. 111: 347 (1935).Google Scholar
  8. 8.
    Robel, P., Emiliozzi, R., and Baulieu, E.E., J. Biol. Chem. 241: 20 (1966).PubMedGoogle Scholar
  9. 9.
    Robel, P., Emiliozzi, R., and Baulieu, E.E., Compt. Rend. Acad. Sci. 261:4886 (1965); J. Biol. Chem. (in press).Google Scholar
  10. 10.
    Wengle, B., and Boström, H., Acta Chem. Scand. 16: 502 (1962).CrossRefGoogle Scholar
  11. 11.
    Edwards, R. W. H., Kellie, A.E., and Wade, A. P., Mem. Soc. Endocrinol. 2: 53 (1953).Google Scholar
  12. 12.
    MacKenna, J., and Norymberski, K. J., Biochem. J. 76: 60 (1960).Google Scholar
  13. 13.
    Crépy, O., Jayle, M.F., and Meslin, R., Acta Endocrinol. 24: 233 (1957).PubMedGoogle Scholar
  14. 14.
    Siiteri, P., Ph.D. dissertation, Columbia University (1962).Google Scholar
  15. 15.
    Siiteri, P., Steroids 2: 687 (1963).CrossRefGoogle Scholar
  16. 16.
    Schneider, J. J., and Lewbart, M. L., Recent Progress in Hormone Research, Vol. 15, Academic Press, New York, 1959, p. 201.Google Scholar
  17. 17.
    Cavina, G., Bull. Soc. Ital. Biol. Sper. 31: 1666 (1955).Google Scholar
  18. 18.
    Calvin, H.I., Van de Wiele, R.L., and Lieberman, S., Biochemistry 2: 648 (1963).CrossRefPubMedGoogle Scholar
  19. 19.
    Roberts, K. D., Bandi, L., Calvin, H. I., Drucker, W. D., and Lieberman, S., Biochemistry 3: 1983 (1964).CrossRefPubMedGoogle Scholar
  20. 20.
    Sandberg, E., Gurpide, E., and Lieberman, S., Biochemistry 3: 1256 (1964).CrossRefPubMedGoogle Scholar

Copyright information

© New England Nuclear Corporation 1966

Authors and Affiliations

  • E. E. Baulieu
    • 1
  • R. Emiliozzi
    • 1
  • M. C. Lebeau
    • 1
  • C. Corpéchot
    • 1
  • P. Robel
    • 1
  1. 1.Unité de Recherches sur le Métabolisme Moléculaire et la Physio-Pathologie des Stéroides (INSERM) Laboratoire de Chimie BiologiqueFaculté de MédecineParisFrance

Personalised recommendations