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Studies of the Secretion and the Metabolism of Steroid Conjugates: Synthesis, Analysis, and Use of Doubly Labeled Compounds

  • E. E. Baulieu
  • R. Emiliozzi
  • M. C. Lebeau
  • C. Corpéchot
  • P. Robel

Abstract

The conjugated steroids, namely, the hemi-esters of sulfuric acid (sulfates, S) and the β-D-glucopyranuronosides (glucuronides, G) were considered as detoxication forms of the hormones and their metabolites. Recently, the adrenal cortical secretion of dehydroisoandrosterone sulfate (DS) [1] and the metabolic transformation of this compound into other compounds and especially other steroid conjugates were shown, and renewed the interest in their study [2,3]. Some problems concerning the synthesis and analysis of steroid conjugates and the application of the methods so described to biochemical research will be considered.

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Copyright information

© New England Nuclear Corporation 1966

Authors and Affiliations

  • E. E. Baulieu
    • 1
  • R. Emiliozzi
    • 1
  • M. C. Lebeau
    • 1
  • C. Corpéchot
    • 1
  • P. Robel
    • 1
  1. 1.Unité de Recherches sur le Métabolisme Moléculaire et la Physio-Pathologie des Stéroides (INSERM) Laboratoire de Chimie BiologiqueFaculté de MédecineParisFrance

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