Use of Vinyl Magnesium Bromide in the Synthesis of Labeled Compounds: New Preparations of Glycerol-1-C14 and Glyceric Acid-1-C14

  • L. Pichat
  • M. Herbert
  • F. Aubert


The biological importance of glycerol and glyceric acid is well known; as a consequence, it is very useful to have methods for the labeling of these compounds ith C14. An improved method for the synthesis of glyceric acid-1-C14 has recently been described by Ashworth in England [1]. However, especially in the case of glycerol, the published methods are time-consuming and the overall yield is fairly low.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Ashworth, J. M., J. Chem. Soc. 2563 (1963).Google Scholar
  2. 2.
    Normant, H., Bull. Soc. Chim. France 728 (1957).Google Scholar
  3. 3.
    Sulima, L. V., Chem. Abst. 57: 12302a (1962).Google Scholar
  4. 4.
    Benedict, G. E., and Russell, R. R., J. Am. Chem. Soc. 73: 5444 (1951).CrossRefGoogle Scholar
  5. 5.
    Pajaro, G., and Valvassori, A., Gazz. Chim. Italiana 92: 1446 (1962).Google Scholar
  6. 6.
    Hochstein, F. A., and Brown, W.G., J. Am. Chem. Soc. 70: 3484 (1948).CrossRefGoogle Scholar
  7. 7.
    Nystrom, R. F., J. Am. Chem. Soc. 81: 610 (1959).CrossRefGoogle Scholar
  8. 8.
    Pichat, L., Herbert, M., and Aubert, F., J. Labelled Compds. 1: 66 (1965).CrossRefGoogle Scholar

Copyright information

© New England Nuclear Corporation 1966

Authors and Affiliations

  • L. Pichat
    • 1
  • M. Herbert
    • 1
  • F. Aubert
    • 1
  1. 1.Service des Molecules MarquéesCentre D’Études Nucléaires SaclayGiF/Yvette (91)France

Personalised recommendations