Use of Different Isotopes in the Study of Cell Differentiation

  • J. H. Veerkamp


Cytodifferentiation has important intrinsic and extrinsic determinants: factors within and from outside the cell influence the development of the cell in embryonal tissues. Two kinds of interactions between cells are possible, homotypic (between like cells) and heterotypic (between cells of unlike developmental history and potentialities). Intracellular control mechanisms on genetic and epigenetic levels will react upon input from beyond the membrane. Embryonic induction may not involve a single step at the genetic level, the direct initiation of synthesis of differentiated product, but can work at various stages of the control circuits [1].


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  1. 1.
    Grobstein, C., in Locke, M., Cytodifferentiation and Macromolecular Synthesis, Academic Press, New York, 1963, p. 1.CrossRefGoogle Scholar
  2. 2.
    Holzer, H., Thirteenth Colloquium der Gesellschaft fur Physiologische Chemie, Springer-Verlag, Berlin, 1963, p. 217.Google Scholar
  3. 3.
    Strudel, G., Arch. Anat. Microscop. Morphol..Exp. 44: 209 (1955).Google Scholar
  4. 4.
    Lash, J. W., in Locke, M., Cytodifferentiation and Macromolecular Synthesis, Academic Press, New York, 1963, p. 235.CrossRefGoogle Scholar
  5. 5.
    Avery, G., Chow, M., and Holzer, H., J. Exp. Zool. 132: 409 (1956).CrossRefGoogle Scholar
  6. 6.
    Simms, H. J., and Sanders, M., AMA Arch. Pathol. 33: 619 (1942).Google Scholar
  7. 7.
    Jeffay, H., Olubajo, F.A., and Jewell, W.R., Anal. Chem. 32: 306 (1960).CrossRefGoogle Scholar
  8. 8.
    Siekevitz, P., J. Biol. Chem. 195: 549 (1952).Google Scholar
  9. 9.
    Bray, G.A., Anal. Biochem. 1: 279 (1960).CrossRefGoogle Scholar
  10. 10.
    Wu, R., Anal. Biochem. 7: 207 (1964).CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Peng, C.T., Anal. Chem. 36: 2456 (1964).CrossRefGoogle Scholar
  12. 12.
    Dulcino, J., Bosco, R., Verly, W.G., and Maisin, J.R., Clin. Chim. Acta 8: 58 (1963).CrossRefGoogle Scholar
  13. 13.
    Rutter, W. J., Wessels, N. K., and Grobstein, C., Natl. Cancer Inst. Monograph 13: 51 (1963).Google Scholar
  14. 14.
    Zajicek, G., and Gross, J., Exp. Cell Res. 34: 138 (1964).CrossRefPubMedGoogle Scholar

Copyright information

© New England Nuclear Corporation 1966

Authors and Affiliations

  • J. H. Veerkamp
    • 1
  1. 1.Department of BiochemistryUniversity of NijmegenNijmegenThe Netherlands

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