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The Biosynthesis of Prostaglandin-E1 Studied with Specifically 3H-Labeled Precursors

  • Bengt Samuelsson

Abstract

It was recently shown that 5,8,11,14-eicosatetraenoic acid is a precursor of prostaglandin-E2 (PGE2) in homogenates of the vesicular gland of sheep [1,2]. The conversion of 8,11,14-eicosatrienoic acid [3,4] and 5,8,11,14,17-eicosapentaenoic acid [3] into PGE1 and PGE3, respectively, was also demonstrated later using the same system. In homogenates of guinea pig lung, however, 5,8,11,14-eicosatetraenoic acid was transformed into both PGE2 and PGF2 and also into metabolites of these two compounds [5].

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Copyright information

© New England Nuclear Corporation 1966

Authors and Affiliations

  • Bengt Samuelsson
    • 1
  1. 1.Department of ChemistryKarolinska InstituteStockholmSweden

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