Application of Double Isotope Labeling to the Study of the Metabolism of Ascites Tumor Cells under the Influence of Glyceraldehyde

  • M. Wenzel
  • I. Joel
  • W. Oelkers


There are many reports in the literature dealing with the metabolic fate of the carbon atoms of glucose in various tissues. Little is known, however, about the metabolic fate of distinct hydrogen atoms of the glucose molecule in normal or tumor tissues. Such information may have special significance with respect to understanding the abnormal growth characteristics of malignant tissues, since these hydrogen atoms are not only oxidized to water, but also can be used for the reduction of organic substrates.


Biochemical Application Ascites Cell Oxaloacetic Acid Ketoglutaric Acid Glucose Metabolite 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Forster, D., and Bloom, B., J. Biol. Chem. 236: 2548 (1962).Google Scholar
  2. 2.
    Lowenstein, J.M., J. Biol. Chem. 235: 1213 (1961).Google Scholar
  3. 3.
    Warburg, O., Gawehn, K., Geissler, A., and Lorenz, S., Z. Kiin. Chem. 1: 175 (1963).Google Scholar
  4. 4.
    Wenzel, M., Naturwissenschaften 52: 129 (1965).CrossRefGoogle Scholar
  5. 5.
    Mendel, B., Sterlitz, F., and Mundell, D., Nature (London) 141: 288 (1938).CrossRefGoogle Scholar
  6. 6.
    Lardy, H.A., Wiebelhaus, V.D., and Mann, K.M., J. Biol. Chem. 187: 325 (1950).Google Scholar
  7. 7.
    Wenzel, M., Joel, I., and Oelkers, W., Naturwissenschaften 53: 82 (1966).CrossRefGoogle Scholar

Copyright information

© New England Nuclear Corporation 1966

Authors and Affiliations

  • M. Wenzel
    • 1
  • I. Joel
    • 1
  • W. Oelkers
    • 1
  1. 1.Physiologisch-Chemisches InstitutFreien Universität Berlin Berlin-DahlemGermany

Personalised recommendations