Use of Tracers in the Study of Biogenic Amine Compartments

  • Michael A. Beaven


Although a biologist may learn much about the individual enzyme reactions present in a tissue homogenate, this knowledge will not by itself explain intrinsic physiological mechanisms in the living organism. Function is inextricably linked with structural integrity, and this is destroyed by homogenization. Atissue organ is a physical machine, and to explain its physiological function one needs to know not only of what substances it is composed, but how these are physically arranged and how they change to make the engine work.


Nerve Ending Transfer Rate Constant Active Transport System Radioactive Equilibration Reserve Pool 


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  1. 1.
    Brodie, B. B., and Beaven, M. A., Med. Exptl. 8: 320 (1963).Google Scholar
  2. 2.
    Montanari, R., Beaven, M.A., Costa, E., and Brodie, B. B., Life Science 2: 232 (1963).CrossRefGoogle Scholar
  3. 3.
    Euler, U.S. V., and Hillarp, N.A., Nature 177: 44 (1900).CrossRefGoogle Scholar
  4. 4.
    Potter, L. J., and Axelrod, J., Nature 194: 581 (1962).CrossRefGoogle Scholar
  5. 5.
    Hertting, S., Axelrod, J., Kopin, I. J., and Whitby, G., Nature 189: 66 (1961).CrossRefGoogle Scholar
  6. 6.
    Hertting, S., and Hess, S.M., Experientia 18: 214 (1962).CrossRefGoogle Scholar
  7. 7.
    Kopin, I. J., and Bridgers, W., Life Sciences 2: 356 (1963).CrossRefGoogle Scholar
  8. 8.
    Beaven, M. A., and Maickel, R. P., Biochem. Biophys. Res. Commun. 14: 509 (1964).CrossRefGoogle Scholar
  9. 9.
    Maickel, R. P., Beaven, M.A., and Brodie, B.B., Life Sciences 2: 953 (1963).CrossRefGoogle Scholar
  10. 10.
    Potter, L. T., Axelrod, J., and Kopin, I. J., Biochem. Pharmacol. 11: 254 (1962).CrossRefGoogle Scholar
  11. 11.
    Nash, C. W., Costa, E., and Brodie, B. B., Pharmacologist 5: 258 (1963).Google Scholar
  12. 12.
    Berman, M., and Schoenfeld, R., J. Appl. Phys. 27: 1361 (1956).CrossRefGoogle Scholar

Copyright information

© New England Nuclear Corporation 1965

Authors and Affiliations

  • Michael A. Beaven
    • 1
  1. 1.Laboratory of Chemical PharmacologyNational Heart InstituteBethesdaUSA

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