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The Use of DMO-2-C14 (5, 5 -Dimethyl- 2, 4-Oxazolidinedione-2-C14) and Inulin-Carboxyl-C14 for Measurement of Intracellular pH

  • Thomas C. Butler

Abstract

One of the chemical characteristics of the intracellular water that is of the greatest interest is its pH value. Since numerous biochemical reactions involve the transfer of protons, or are influenced by the availability of protons, it is evident that no adequate study of such reactions can be made without knowledge of the chemical potential of the proton, of which pH is an index. Many assumptions have been made concerning the pH of intracellular water and many attempts have been made to measure it, but actual knowledge of the intracellular pH of mammalian cells has been meager and unsatisfactory.

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References

  1. 1.
    Caldwell, P. C., Intern. Rev. Cytol. 5: 229 (1956).CrossRefGoogle Scholar
  2. 2.
    Waddell, W. J., and Butler, T.. C., J. Clin. Invest. 38: 720 (1959).CrossRefGoogle Scholar
  3. 3.
    Butler, T. C., and Davidson, J.D., J. Pharm. Sci. 52: 1110 (1963).CrossRefGoogle Scholar
  4. 4.
    Poole, D. T., Butler, T. C., and Waddel, W. J., J. Natl. Cancer Inst. 32: 939 (1964).Google Scholar

Copyright information

© New England Nuclear Corporation 1965

Authors and Affiliations

  • Thomas C. Butler
    • 1
  1. 1.Department of PharmacologyUniversity of North CarolinaChapel HillUSA

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