Clinical Use of the Arm Counter in Blood Clearance Studies
Foreman  suggested in 1953 that a liquid scintillation detector designed specifically to measure radioactivity circulating through the human forearm would be useful in clinical diagnosis. The annular detector, constructed to measure conveniently the human arm in vivo, reduced the number of required photomultiplier tubes without appreciable loss of counting efficiency and minimized the mass of shielding needed for a low background. This detector was found to be an excellent means of measuring radioactivity in the circulation of the arm, and in early trials it also proved to be a facile means of measuring small amounts of radiation in whole mice, rats, or other small animals [2, 3]. It could also be used as a large well counter to assay the radioactivity of 500- to 1000-ml samples of urine, feces, and blood. With most gamma-emitting isotopes in amorphous or variably shaped specimens, effects of thickness were easily minimized by counting all samples of excreta after they were made up to 500 ml in a disposable quart ice-cream carton.
KeywordsRose Bengal Liquid Scintillation Detector Clinical Diagnostic Test Alamos Scientific Laboratory Clinical Methodology
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