Tritium Gas Exposure Labeling

  • Kenneth E. Wilzbach


The exposure of organic compounds to tritium gas [1] has received considerable attention in the past few years and has become an accepted method for tritium labeling. Experience has confirmed the initial report that activities in the range of 1–100 mc/g are generally obtained by exposure to curie amounts of tritium for several days, and that labeling is accompanied by the formation of tritiated by-products of high specific activity. Information on the distribution of tritium in labeled products and on the nature of the by-products has also been accumulated. Results obtained are summarized here to provide a firmer basis for assessing the limitations and the area of usefulness of the method.


Methyl Oleate High Specific Activity Radiochemical Purity Mandelic Acid Tritium Label 


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  1. (1).
    Wilzbach. J. Am. Chem. Soc. 79, 1013 (1957).CrossRefGoogle Scholar
  2. (2).
    Rosenblum. Nucleonics 17, No. 12, 80 (1959).Google Scholar
  3. (3).
    Roth et al. J. Am. Pharm. Assn. 48, 415 (1959).CrossRefGoogle Scholar
  4. (4).
    Wilzbach. This volume, p. 4.Google Scholar
  5. (5).
    Riesz and Wilzbach. 134th Meeting Am, Chem. Soc. Chicago, September, 1958.Google Scholar
  6. (6).
    Jackson and Kittinger. Private communication.Google Scholar
  7. (7).
    Dutton and Nystrom. This volume, p. 18.Google Scholar
  8. (8).
    Spratt et al. Int. J. Appl. Rad & Isotopes 2, 167 (1957).CrossRefGoogle Scholar
  9. (9).
    v. Holt et al. Proc. II U.N. Int. Conf. Peaceful Uses Atomic Energy, Geneva, 1958, Vol. 25, p. 230. Also, v. Holt et al. Biochim. et Biophys. Acta 38, 88 (1960).Google Scholar
  10. (10).
    Ghanem and Westermark. I.A.E.A. Int. Conf. Uses of Radioisotopes, Copenhagen, 1960.Google Scholar
  11. (11).
    Lemmon et al. Science 129, 1740 (1959).CrossRefGoogle Scholar
  12. (12).
    Dorfman and Wilzbach. J. Phys. Chem. 63, 799 (1959).CrossRefGoogle Scholar
  13. (13).
    Jackson et al. Nucleonics 18, 8, 102 (1960).Google Scholar
  14. (14).
    Wilzbach. I.A.E.A. Int. Conf. Uses of Radioisotopes, Copenhagen, 1960.Google Scholar
  15. (15).
    Mottlau. J. Phys. Chem. 64, 931 (1960).CrossRefGoogle Scholar

Copyright information

© New England Nuclear Corporation 1963

Authors and Affiliations

  • Kenneth E. Wilzbach
    • 1
  1. 1.Argonne National LaboratoryArgonneUSA

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