Measuring Turnover Rates in the Nonsteady State
It is very difficult to define the steady and nonsteady biological states precisely. If a labeled compound is introduced into a non-growing, healthy (and presumably “steady-state”) animal, the specific activity of the labeled compound is found to decrease with time. This decrease has been interpreted as being due to the turnover of the substance. There is also a decrease in specific activity when the same procedure is carried out in animals obviously not in a steady state (growth, wasting disease, etc.). However, this latter specific activity decrease may or may not be due to the turnover of the substance.
KeywordsTurnover Rate Pool Size Label Product Label Compound Label Precursor
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