Abstract
Tracer experiments have suffered the pains of all new endeavors, namely, a multiplicity of definitions and frequent inadequacy of terminology. Let us, therefore, begin the presentation with a set of definitions and suggestions of preferred usage.
Presented at the Third Symposium on Advances in Tracer Methodology, 1959.
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References
Aronoff, S. “Techniques of Radiobiochemistry,” p. 75, Iowa State College Press, Ames, Iowa (1956).
Brownell, G. L., Cavicchi, R. V., and Perry, K. E. “An Electrical Analog for Analysis of Compartmental Biological Systems,” Rev. Sci. Instr. 24, 704 (1953).
Comar, C. L. “Radioisotopes in Biology and Agriculture,” p. 1, McGraw-Hill, New York (1955).
Garavaglia, C., Polvani, C., and Silverstrini, R. “A Collection of Curves Obtained with a Hydrodynamic Model Simulating Some Schemes of Biological Experiments Carried Out with Tracers,” Report No. 60 Centro Informazioni Studi Esperienze, Milan (1958).
Lax, L. C. and Wrenshall, G. A. “Measurement of Turnover Rates in Systems of Hydrodynamic Pools Out of Dynamic Equilibrium,” Nucleonics 11, 18 (1953).
Reiner, J. M. “The Study of Metabolic Turnover Rates by Means of Isotopic Tracers,” Arch. Biochem. Biophys, 46, 53 (1953).
Robertson, J. S. “Theory and Use of Tracers in Determining Transfer Rates in Biological Systems,” Physiol. Rev. 37, 133 (1957).
Russell, J. A. “The Use of Isotopic Tracers in Estimating Rates of Metabolic Reactions,” Perspectives in Biol. and Med. 1, 138 (1958).
Schacter, H. “Direct Versus Tracer Measurement of Transfer Rates in a Hydrodynamic System Containing a Compartment Whose Contents Do Not Intermix Rapidly,” Canad. J. Biochem. Physiol. 33, 940 (1955).
Schoenheimer, R. “The Dynamic State of Body Constituents,” Harvard University Press, Cambridge (1942).
Siri, W. “Isotopic Tracers and Nuclear Radiations,” p. 395, McGraw-Hill, New York (1949).
Solomon, A. K. “The Kinetics of Biological Processes. Special Problems Connected with the Use of Tracers,” Adv. Biol. Med. Physics 3, 65 (1953).
Zilversmit, D. B., Entenman, C., and Fishier, M. C. “On the Calculation of Turnover Time and Turnover Rate from Experiments Involving the Use of Labeling Agents,” J. Gen. Physiol,. 26, 325 (1943).
Zilversmit, D. B. and Shore, M. L. “A Hydrodynamic Model of Isotope Distribution in Living Organisms,” Nucleonics 10, 32 (1952).
Zilversmit, D. B. “The Design and Analysis of Isotope Experiments,” Am. J. Med. 29, 832 (1960).
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© 1963 New England Nuclear Corporation
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Zilversmit, D.B. (1963). Design and Analysis of Tracer Experiments. In: Rothchild, S. (eds) Advances in Tracer Methodology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8619-3_35
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DOI: https://doi.org/10.1007/978-1-4684-8619-3_35
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