The Red Cell as a Risk Factor in Circulatory Diseases

  • John A. Dormandy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 164)


The vitally essential function of the red cell distributing oxygen through the body has perhaps stopped us from appreciating that the red cells may also represent a risk factor predisposing to circulatory insufficiency. Our recent interest and increasing knowledge of the rheological or flow properties of blood has shown that this risk to the circulation may be manifested in two different ways: by an increase in the whole blood viscosity associated with a raised concentration of red cells, and by a maldistribution of flow in the microcirculation due to increased rigidity of the red cells. The second of these mechanisms is much more speculative.


Blood Viscosity Circulatory Disease Preoperative Haemoglobin High Haematocrit Circulatory Insufficiency 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • John A. Dormandy
    • 1
  1. 1.St. James’ and St. George’s HospitalsLondonEngland

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