Platelets, Hypoxemia and Pulmonary Hypertension

  • Giuseppe G. Nenci
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 164)


The capacity of hypoxia to induce pulmonary hypertension (PH) in animals and in man has been known for many years (von Euler and Liljestrand, 1974; Motley et al., 1974). Some evidence exists that platelets may undergo changes in function and in number because of an altitude hypoxemia (Sharma et al., 1979; Sharma, 1980). This, together with altitude decompression, may even lead to a pulmonary sequestration of platelets (Gray et al., 1975). Nevertheless, it seems doubtful that platelets significantly contribute to the enhancement of pulmonary vascular resistance induced by hypoxia.


Pulmonary Hypertension Patent Ductus Arteriosus Pulmonary Vascular Resistance Primary Pulmonary Hypertension Hypoxic Pulmonary Vasoconstriction 
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  1. Abraham, A.S., Cole, R.B., Bishop, J.M., 1968, Reversal of pulmonary hypertension by prolonged oxygen administration to patients with chronic bronchitis. Circ. Res. 23:147.PubMedCrossRefGoogle Scholar
  2. Blass, K.E., Block, H.U., Förster, W., Pönicke, K., 1980, Dipyridamole, a potent stimulator of Prostacyclin (PGI2) biosynthesis. Br. J. Pharmacol. 68:71.PubMedCrossRefGoogle Scholar
  3. Bø, G., Hognestad, J., 1972, Effects on the pulmonary circulation of suddenly induced intravascular aggregation of blood platelets. Acta Physiol. Scand. 85:523.PubMedCrossRefGoogle Scholar
  4. Boysen, P.G., Block, A.J., Wynne, J.W., Hunt, L.A., Flick, M.R., 1979, Nocturnal pulmonary hypertension in patients with chronic obstructive pulmonary disease. Chest 76:536.PubMedCrossRefGoogle Scholar
  5. Dusting, J.D., Moneada, S., Vane, J., 1979, Prostaglandins, their intermediates and precursors: cardiovascular actions and regulatory roles in normal and abnormal circulatory systems. Prog. Cardiovasc. Dis. 21:405.PubMedCrossRefGoogle Scholar
  6. von Euler, V.S., Liljestrand, G., 1947, Observation on the pulmonary arterial blood pressure in the cat. Acta Physiol. Scand. 12:301.CrossRefGoogle Scholar
  7. Friedman, W.F., Hirschklau, M.G., Printz, M.P., Pitlik, P.T., Kirkpatrick, S.E., 1976, Pharmacological closure of patent ductus arteriosus in the premature infant. N. Engl. J. Med. 295:526.PubMedCrossRefGoogle Scholar
  8. Gray, J.W., Bryan, A.C., Freedman, M.H., Houston, C.S., Lews, W.F., McFadden, D.M., Newell, G., 1975, Effect of altitude exposure on platelets. J. Appl. Physiol. 39:648.PubMedGoogle Scholar
  9. Gryglewski, R.J., Korbut, R., Ocetkeiwicz, A., 1978, Generation of prostacyclin by lungs in vivo and its release into the arterial circulation. Nature 273:765.PubMedCrossRefGoogle Scholar
  10. Hales, C.A., Rouse, E.T., Slate, J.L., 1978, Influence of aspirin and indomethacin on variability of alveolar hypoxic vasoconstriction. J. Appl. Physiol. 45:33.PubMedGoogle Scholar
  11. Hechtman, H.B., Lonergan, E.A., Staunton, H.P.B., Dennis, R.C., Shepro, D., 1978, Pulmonary entrapment of platelets during acute respiratory failure. Surgery 83:277.PubMedGoogle Scholar
  12. Hyman, A.L., Spannhake, E.W., Kadowitz, P.F., 1978, Prostaglandins and the lung. Am. Rev. Resp. Dis. 117:111.PubMedGoogle Scholar
  13. Johnson, T.S., Ellis, J.H., Steele, P.P., 1978, Improvement of platelet survival time with oxygen in patients with chronic obstructive airways disease. Am. Rev. Resp. Dis. 117:255.PubMedGoogle Scholar
  14. Jorgensen, K.A., Pyerberg, J., Stoffersen, E., 1979, Prostacyclin (PGI2) and the effect of phosphodiesterase inhibitors on platelet aggregation. Pharm. Res. Commun. 11:605.CrossRefGoogle Scholar
  15. Kirby, B.J., 1980, Relationship between pulmonary gas exchange and pulmonary hypertension in chronic obstructive lung disease. Bull. Europ. Physiopath. Resp. 16:74.Google Scholar
  16. Kjeldsen, K., 1975, The effect of hypoxia on the fine structure of the aortic intima of rabbits. Lab. Invest. 33:533.PubMedGoogle Scholar
  17. Levine, B.E., Bigelow, P.B., Hamstra, R.O., et al., 1967, The role of long term continuous oxygen administration in patients with chronic airway obstruction with hypoxemia. Ann. Intern. Med. 66:639.PubMedGoogle Scholar
  18. Mlczoch, J., Tucker, A., Weir, E.K., Reeves, J.T., Grover, R.F., 1978, Platelet-mediated pulmonary hypertension and hypoxia during pulmonary microembolism. Reduction by platelet inhibition. Chest 74:684.CrossRefGoogle Scholar
  19. Moncada, S., Korbut, R., 1978, Dipyridamole and other phosphodiesterase inhibitors act as antithrombotic agents by potentiating endogenous prostacyclin. Lancet 1:1286.PubMedCrossRefGoogle Scholar
  20. Motley, H.L., Cournand, A., Werko, L. et al., 1947, The influence of short periods of induced acute anoxia upon pulmonary artery pressure in man. Am. J. Physiol. 150:315.PubMedGoogle Scholar
  21. Nagasaka, Y., Hiroshi, A., Lee, Y.S., et al., 1978, Long-term favourable effect of oxygen administration on a patient with primary pulmonary hypertension. Chest 74:299.PubMedCrossRefGoogle Scholar
  22. Neri Serneri, G.G., Masotti, G., Poggesi, L., Galanti, G., Castellani, S., Dipyridamole stimulates prostacyclin biosynthesis in man and in vitro. In: 6th International Congress on Thrombosis, Mediterranean League Against Thromboembolic Diseases, Monte-Carlo, October 23–25, 1980.Google Scholar
  23. O’Brien, J.R., 1980, Platelets and the vessel wall: how much aspirin? Lancet 1:372.PubMedGoogle Scholar
  24. Person, B., Proctor, R., 1979, Primary pulmonary hypertension: response to indomethacin, terbutaline and isoproterenol. Chest 76:601.PubMedCrossRefGoogle Scholar
  25. Rådegran, K., Bergentz, S.E., Lewis, D.H., Ljungquist, U., Olsson, P., 1971, Pulmonary effects of induced platelet aggregation. Intravascular obstruction or vasoconstriction? Scand. J. Clin. Lab. Invest. 28:423.PubMedCrossRefGoogle Scholar
  26. Rickaby, D.A., Dawson, C.A., Maron, M.B., 1980, Pulmonary inactivation of serotonin and site of serotonin pulmonary vasoconstriction. J. Appl. Physiol. 48:606.PubMedGoogle Scholar
  27. Rubin, L.J., 1980, The influence of prostaglandin synthesis inhibition on the effects of hydralazine in dogs with hypoxic pulmonary hypertension. Am. Rev. Resp. Dis. 121:444.Google Scholar
  28. Rubin, L.J., Peter, R.H., 1978, Oral hydralazine therapy for primary pulmonary hypertension. N. Engl. J. Med. 302:69.CrossRefGoogle Scholar
  29. Rudolph, A.M., 1978, Effects of prostaglandins and synthetase inhibitors on the fetal circulation. In: Preterm labour, A. Anderson, R. Beard, M. Brudenell, P. Dunn, Eds. Royal College of Obstetricians and Gynaecologists, p. 231–242.Google Scholar
  30. Sharma, S.C., 1980, Platelet count on acute induction to high altitude. Thrombos. Haemostas. 43:29.Google Scholar
  31. Sharma, S.C., Balasubramanian, V., Chadha, K.S., 1979, Platelet adhesiveness in permanent residents of high altitude. Thrombos. Haemostas. 42:1508.Google Scholar
  32. Steele, P., Ellis, J.H., Wiley, H.S., Genton, E., 1977, Platelet survival time in patients with hypoxemia and pulmonary hypertension. Circulation 55:660.PubMedCrossRefGoogle Scholar
  33. Svensson, J., Strandberg, T., Tuveno, T., Hamberg, M., 1977, Thromboxane A2: effects on airway and vascular smooth muscle. Prostaglandins. 14:426.Google Scholar
  34. Tremoli, E., Bertoli, L., Maderna, P., Conti, F., Merlini, R., Mantero, O., 1980, Platelet anti-aggregating therapy in chronic obstructive lung disease. Clin. Resp. Physiol. 16:84.Google Scholar
  35. Wagenvoort, C.A., Wagenvoort N., 1970, Primary pulmonary hypertension: a pathologic study of the lung vessels in 156 clinically diagnosed cases. Circulation 42:1163.CrossRefGoogle Scholar
  36. Wang, S.W.S., Pohl, J.E.F., Rowlands, D.J., Wade, E.G., 1978, Diazoxide treatment of primary pulmonary hypertension. Brit. Heart J. 40:572.PubMedCrossRefGoogle Scholar
  37. Watkins, W.D., Peterson, M.B., Crone, R.K., Shannon, D.C., Levine, L., 1980, Prostacyclin and Prostaglandin E1 for severe idiopathic pulmonary artery hypertension. Lancet 1:1083.PubMedCrossRefGoogle Scholar
  38. Weir, E.K., McMurty, I.F., Tucker, A., Reeves, J.T., Grover, R.F., 1976, Prostaglandin synthetase inhibitors do not decrease hypoxic pulmonary vasoconstriction. J. Appl. Physiol. 41:714.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Giuseppe G. Nenci
    • 1
  1. 1.Institute of Semeiotica Medica, Policlinico MonteluceUniversity of Perugia Medical SchoolPerugiaItaly

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