Clotting System in Prethrombotic State

  • M. R. Boisseau
  • H. Bricaud
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 164)


A short time ago, hypercoagulability in circulating blood was appreciated as an increased activation of coagulation related to more elevated factors than in controls. Thus Whole Blood Thromboela-stography illustrated this state like heparin consumption in vivo and in vitro also did. Meanwhile it quickly appeared that these tests were poorly correlated to thrombogenesis and were much more related to a compensated intravascular disseminated coagulation.


Blood Group Coagulation Factor Clot System Fibrin Monomer Coagulation Disturbance 
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  1. 1.
    H.L. Nossel, J. Yudelman, R.E. Canfield, V.P. Butler, K. Spanondis, G.D. Wilner and G.D. Quershi, Measurement of fibri-nopeptide A in human blood. J. Clin. Invest. 1:43–53 (1974).CrossRefGoogle Scholar
  2. 2.
    O. Egeberg, Inherited antithrombin deficiency causing thrombophilia. Thromb. Diath. Haemorrh. 13:616–530 (1965).Google Scholar
  3. 3.
    J.R. O’Brien, The prothrombotic state. In: Recent advances in blood coagulation, p 241–266, Elsyver Ed, 1979.Google Scholar
  4. 4.
    J.J. Sixma, Techniques for diagnosing prethrombotic states. A review. Thrombos. Haemostas. (Stuttg.) 40:252–259 (1978).Google Scholar
  5. 5.
    H. Stormorken, The thrombo-haemorrhagic balance. Acta Med. Scand. (Suppl.) 642:131–140 (1980).Google Scholar
  6. 6.
    T.W. Meade and W.R.S. North, Population-based distributions of haemostatic variables. Br. Med. Bull. 33, 3, 283–288 (1977).PubMedGoogle Scholar
  7. 7.
    H. Stormorken and J. Erikssen, Plasma antithrombin and factor VIII antigen in relation to angiographic findings, angina and blood groups in middle-aged men. Thrombos. Haemostas. (Stittg.) 38:874–880 (1977).Google Scholar
  8. 8.
    S. Sagar, J.D. Stamatakis, D.P. Thomas and V.V. Kakkar, Oral contraceptives, antithrombin III activity, post operative deep vein thrombosis. Lancet 1: 509–511 (1976).PubMedCrossRefGoogle Scholar
  9. 9.
    E. Marciniak, C.H. Farley, P.A. de Simone, Familial thrombosis due to antithrombin III deficiency. Blood 43:219–221 (1974).PubMedGoogle Scholar
  10. 10.
    V.V. Kakkar, A.N. Nicolandes, Low doses of heparin in the prevention of deep vein thrombosis. Lancet 2:7726–7728 (1871).Google Scholar
  11. 11.
    D.J.S. Hunter, A.B.M. Anderson and M. Haddon, Changes in coagulation factors in postmenopausal women on ethinil oestradiol. Br. J. of Obst, and Gyn. 86:488–490 (1979).CrossRefGoogle Scholar
  12. 12.
    I.M. Nilsson and S. Isacson, New aspects of the pathogenesis of thromboembolism. Progress in Surgery 11:46–68 (1973).PubMedGoogle Scholar
  13. 13.
    K.W.E. Denson, The ratio of factor VIII. Related antigen and factor VIII biological activity as an index of hypercoagulability and vascular clotting. Thrombosis Res. 10:107–119 (1977).CrossRefGoogle Scholar
  14. 14.
    L. Poller, Factor VII and thrombosis. J. of Clin. Pathol. 10: 348–350 (1957).CrossRefGoogle Scholar
  15. 15.
    J.A. Penner, Hypercoagulation and thrombosis. Symposium on advances in haematology. Med. Clinics of North America 64: 743–759 (1980).Google Scholar
  16. 16.
    Y. Sultan, Hypercoagulabilité et thrombose. Ann. Med. Int. 131, 3, 137–140 (1980).Google Scholar
  17. 17.
    M.L. Boffa, Evaluation of the phospholipid-related procoagulant activity in plasma. A new clue for detecting tendency of thrombosis? Thrombosis Res. 17:567–572 (1980).CrossRefGoogle Scholar
  18. 18.
    P.D. Penick, H.R. Roberts and I.I. De Janov, Covert intravascular clotting. Fed. Proc. 24:825–827 (1965).Google Scholar
  19. 19.
    L.W. Gaston, Studies on a family with elevated plasma level of factor V and a tendency to thrombosis. Pediatrics 68:376–378 (1966).Google Scholar
  20. 20.
    O. Egeberg, Inherited anti-thrombin deficiency causing thrombophilia. Thrombos. Diathes. Haemorrh. 13:176–178 (1967).Google Scholar
  21. 21.
    C. Kockum, Radioimmunoassay of fibrinopeptide A: clinical applications. Thrombosis Res. 8:225–227 (1976).CrossRefGoogle Scholar
  22. 22.
    J. Soria, C. Soria, and J.J. Ryckewaert, Competitive radioimmunoassay for fibrinopeptide A. Clinical Applications. In: Abstract book Six. Int. Congress on Thrombosis of the Mediterranean League against thromboembolic disease. Monte Carlo 23–25 October 1980.Google Scholar
  23. 23.
    M. Cronlund, J. Hardin, H.J. Burton, L. Lee, E. Haber and K.J. Bloch, Fibrinipeptide A in plasma of normal subjects and patients with disseminated intravascular coagulation and systemic lupus erythematosus. J. Clin. Invest. 58:142–147 (1976).PubMedCrossRefGoogle Scholar
  24. 24.
    F.W. Peuscher, W.G. van Aken, O.Th.N. Flier, E.A. Stoepman-van Dalen, T.M. Cremer-Goote and J. A. van Mourik, Effect of anticoagulant treatment measured by fibrinopeptide A (fp A) in patients with venous thrombo-embolism. Thrombosis Res. 18:33–43 (1980).CrossRefGoogle Scholar
  25. 25.
    K.H. Lau, J.S. Rosenberg, D.L. Beeler and R.D. Rosenberg, The isolation and characterization of a specific antibody population directed against the prothrombin activation fragments F2 and F1+2. J. Biol. Chem. 254, 18, 8751–8761 (1979).PubMedGoogle Scholar
  26. 26.
    D.L. Heene, F.R. Mathias, Adsorption of fibrinogen derivatives on insolubilized fibrinogen and fibrin monomer. Thrombosis Res. 2:137–139 (1973).CrossRefGoogle Scholar
  27. 27.
    N. Alkjaersig, A. Fletcher and R. Bursten, Association between oral contraceptive use and thromboembolism: a new approach to its investigation based on plasma fibrinogen chromatography. Am. J. Obstet. Gynecol. 122, 2, 189–211 (1975).Google Scholar
  28. 28.
    J. Soria, C. Soria, J.J. Rykewaert, F. Alhens-Gelas, P. Hourdille and M. Boisseau, Kallikrenin-kinin system as a model of proteolytic regulation in normal and some pathological situations. In; Proteases and hormones, M.K. Agarwal Ed. 1979. Elsevier p 67–83.Google Scholar
  29. 29.
    D. Collen, F. De Cook, M. Verstraete, Quantitation of thrombin-antithrombin III Complex in human blood Europ. J. of Clin. Invest. 7:407–409 (1977).CrossRefGoogle Scholar
  30. 30.
    M.F. Lorient, M.R. Boisseau, H. Bricaud, J.P. Manuau and C. Alliere, Réduction de la filterabilité érythrocytaire et accidents vasculaires cérébraux. Etude chez 80 patients. Sem. Hop. Paris 55:27–30 (1979).Google Scholar
  31. 31.
    G.D.O. Lowe, M.M. Drummond, C.D. Forbes, C.R.M. Prentice and J.C. Barbenel, Blood and plasma viscosity in prediction of venous thrombosis. In: Abstract book Six. Int. Congress on Thrombosis of the Mediterranean League against thromboembolic diseases. Monte Carlo 23–25 October 1980.Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • M. R. Boisseau
    • 1
  • H. Bricaud
    • 1
  1. 1.Hôpital Cardiologique de BordeauxBordeaux-PessacFrance

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