Prostaglandins and Hypertension

  • P. C. Weber
  • B. Scherer
  • W. Siess
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 164)

Abstract

The level of arterial blood pressure is set by a complex interrelationship of several mechanisms which influence both blood flow in and resistance of the vascular system. An imbalance which favours those mechanisms that elevate vascular resistance or extracellular volume will result in hypertension. Such alterations may include increased activity of the adrenergic nervous system, of the renin angiotensin system, or excessive secretion of mineralocorticoids. Of equal importance may be an underactivity of blood pressure lowering factors, such as prostaglandins and the kallikrenin-kinin-system. A deficiency of the vasodepressor systems may lead to hypertension even without an increase in the activity of the blood pressure elevating systems. Beside a genetic predisposition, exogenous risk factors are assumed to play a major role in the natural history of essential hypertension and arterial vascular disease. The contribution of prostaglandins to the etiology of these cardiovascular disorders may be based on an inherent abnormality of the prostaglandin system as well as on the effects of major risk factors such as dietary intake of sodium and fat on prostaglandin formation.

Keywords

Lipase Angiotensin Prostaglandin Norepinephrine Thrombin 

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • P. C. Weber
    • 1
  • B. Scherer
    • 1
  • W. Siess
    • 1
  1. 1.Medizinische Klinik Innenstadt8 München 2Germany

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