Prostaglandins and Hypertension

  • P. C. Weber
  • B. Scherer
  • W. Siess
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 164)


The level of arterial blood pressure is set by a complex interrelationship of several mechanisms which influence both blood flow in and resistance of the vascular system. An imbalance which favours those mechanisms that elevate vascular resistance or extracellular volume will result in hypertension. Such alterations may include increased activity of the adrenergic nervous system, of the renin angiotensin system, or excessive secretion of mineralocorticoids. Of equal importance may be an underactivity of blood pressure lowering factors, such as prostaglandins and the kallikrenin-kinin-system. A deficiency of the vasodepressor systems may lead to hypertension even without an increase in the activity of the blood pressure elevating systems. Beside a genetic predisposition, exogenous risk factors are assumed to play a major role in the natural history of essential hypertension and arterial vascular disease. The contribution of prostaglandins to the etiology of these cardiovascular disorders may be based on an inherent abnormality of the prostaglandin system as well as on the effects of major risk factors such as dietary intake of sodium and fat on prostaglandin formation.


Essential Hypertension Renin Release Renin Secretion Essential Hypertensive Patient Prostaglandin Formation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    K. Abe, M. Yasujima, N. Irokawa, M. Seino, S. Chiba, Y. Sakurai, M. Sato, Y. Imai, K. Saito, T. Ito, T. Haruyama, Y. Otsuka and K. Yoshinaga, 1978, The role of intrarenal vasoactive substances in the pathogenesis of essential hypertension. Clin. Sci. Mol. Med. 55:363s-366s.Google Scholar
  2. 2.
    I. Ahnfelt-Ronne and E. Arrigoni-Martelli, 1978, Increased PGF synthesis in renal papilla of spontaneously hypertensive rats. Biochem. Pharmacol. 27:2363–2367.PubMedCrossRefGoogle Scholar
  3. 3.
    T.K. Bills, J.B. Smith and M.J. Silver, 1976, Metabolism of 14C arachidonic acid by human platelets. Biochem. Biophys. Acta 424:303–314.PubMedCrossRefGoogle Scholar
  4. 4.
    D.L. Birkle, C.K. Ellis and E.F. Ellis, 1980, Norepinephrine inhibits 6-keto-PGF synthesis and stimulates PGF synthesis in feline cerebral cortex homogenates. Fed. Proc. 39:1103.Google Scholar
  5. 5.
    D.B. Case, W.J. Casarella, J.H. Laragh, D.L. Flower and P.J. Canon, 1978, Renal cortical blood flow and angiography in low- and normal-renin essential hypertension. Kidney Int. 13:236.PubMedCrossRefGoogle Scholar
  6. 6.
    J. Colina-Chourio, J.C. McGiff and A. Nasjletti, 1979, Effect of indomethacin on blood pressure in the normotensive un-anaesthetized rabbit: Possible relation to prostaglandin synthesis inhibition. Clin. Sci. 57:359–365.PubMedGoogle Scholar
  7. 7.
    H.U. Comberg, S. Heyden, C.G. Hames, A.J. Vergroesen and A.I. Fleischman, 1978, Hypotensive effect of dietary prostaglandin precursor in hypertensive man. Prostaglandins 15:193–197.CrossRefGoogle Scholar
  8. 8.
    D. Davila, T. Davila, E. Oliw and E. Anggard, 1977, The influence of dietary sodium on urinary prostaglandin excretion. Acta Physiol. Scand. 103:100–106.CrossRefGoogle Scholar
  9. 9.
    M.J. Dunn and V.L. Hood, 1977, Prostaglandins and the kidney. Am. J. Physiol. 233:F-169–F-184.Google Scholar
  10. 10.
    J. Dyerberg, H.O. Bang, E. Stoffersen, S. Moncada and J.R. Vane, 1978, Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis? The Lancet 2:117–119CrossRefGoogle Scholar
  11. 11.
    M. Esler, S. Julius, A. Zweifler, O. Randall, E. Harburg, H. Gardiner and V. DeQuattro, 1977, Mild high-renin essential hypertension: Neurogenic human hypertension? N. Engl. J. Med. 296:405–411.PubMedCrossRefGoogle Scholar
  12. 12.
    M. Hamberg, J. Svensson and B. Samuelsson, 1975, Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. Proc. Natl. Acad. Sci. USA 72:2994–2998.PubMedCrossRefGoogle Scholar
  13. 13.
    P. Hedquist, 1976, Prostaglandin action on transmitter release at adrenergic neuroeffector junctions. In: Advances in prostaglandin and thromboxane research, Vol. 1, B. Samuelsson, R. Paoletti edit., Raven Press, New York, pp. 357–363.Google Scholar
  14. 14.
    W. Hollander, 1976, Role of hypertension in atherosclerosis and cardiovascular disease. Am. J. Cardiol. 38:786–800.PubMedCrossRefGoogle Scholar
  15. 15.
    S. Julius and M. Esler, 1976, Increased central blood volume: a possible pathophysiological factor in mild low-renin essential hypertension. Clin. Sci. Mol. Med. 51:207s-210s.Google Scholar
  16. 16.
    P.B.A. Kernoff, A.L. Willis, K.J. Stone, J.A. Davies and G.P. McNicol, 1977, Antithrombotic potential of dihomo-gammalinolenic acid in man. Br. Med. J. 2:1441–1444.PubMedCrossRefGoogle Scholar
  17. 17.
    C.R. Lake, M.G. Ziegler, M.D. Coleman and I.J. Copin, 1977, Age-adjusted plasma norepinephrine levels are similar in normotensive and hypertensive subjects. N. Engl. J. Med. 296:208–209.PubMedCrossRefGoogle Scholar
  18. 18.
    L. Levine and M.A. Moskowitz, 1979, α- and β-adrenergic stimulation of arachidonic acid metabolism in ‘cells in culture. Proc. Natl. Acad. Sci. USA 76:6632–6636.PubMedCrossRefGoogle Scholar
  19. 19.
    R. Lorenz, U. Spengler, W. Siess, P.C. Weber, 1980, Einfluss veränderter Prostaglandin-Bildung auf die sympathoadrenerge Aktivität und die Blutdruckregulation. Verhdl. Deutsch. Ges. für Inner Medizin, Wiesbaden 1980, in press.Google Scholar
  20. 20.
    S. Moncada and J.R. Vane, 1979, The role of prostacyclin in vascular tissue. Fed. Proceedings 38:66–71.Google Scholar
  21. 21.
    A. Nasjletti and K.U. Malik, 1979, Relationships between the Kallikrenin-kinin and prostaglandin systems. Life Sci. 25: 99–110.PubMedCrossRefGoogle Scholar
  22. 22.
    Ph. Needleman, M.O. Whitaker, A. Wyche, K. Watters, H. Sprecher and A. Raz, 1980, Manipulation of platelet aggregation by prostaglandins and their fatty acid precursors: Pharmacological basis for a therapeutic approach. Prostaglandins 19: 165–181.PubMedCrossRefGoogle Scholar
  23. 23.
    A.A. Nekrasova, R.N. Sokolova, Yu. Levitskaya, N.V. Speranskaya, V.P. Kulagina and N.P. Leghonkays, 1980, Prostaglandins of blood vessels and vessel reactivity in rats receiving sodium chloride and indomethacin. In: Advances in prostaglandin and thromboxane research, Vol. 7, B. Samuelsson, R. Paoletti edit., Raven Press. New York, pp. 1139–1143.Google Scholar
  24. 24.
    P.M.S. O’Brien and F.B. Pipkin, 1979, The effects of deprivation of prostaglandin precursors on vascular sensitivity to angiotensin II and on the kidney in the pregnant rabbit. Br. J. Pharmac. 65:29–34.CrossRefGoogle Scholar
  25. 25.
    O. Olez, R. Olez, H.R. Knapp, B.J. Sweetman and J.A. Oates, 1977, Biosynthesis of prostaglandin D: formation by human platelets. Prostaglandins 13:225–234.CrossRefGoogle Scholar
  26. 26.
    Th. Philipp, A. Distler and U. Cordes, 1978, Sympathetic nervous system and blood-pressure control in essential hypertension. The Lancet 2:959–963.CrossRefGoogle Scholar
  27. 27.
    J. Rosenthal, P.G. Simone and A. Silbergleit, 1974, Effects of prostaglandin deficiency on natriuresis, diuresis, and blood pressure. Prostaglandins 5:435–440.PubMedCrossRefGoogle Scholar
  28. 28.
    B. Samuelsson, M. Goldyne, M. Granström, M. Hamberg, S. Hammarström and C. Malmsten, 1978, Prostaglandins and thromboxanes. Ann. Rev. Biochem. 47:997–1029.PubMedCrossRefGoogle Scholar
  29. 29.
    M.A.D.H. Schalekamp, M.P.A. Schalekamp-Kuyken and W.H. Birkenhäger, 1970, Abnormal renal haemodynamics and renin suppression in hypertensive patients. Clin. Sci. 38:101–110.PubMedGoogle Scholar
  30. 30.
    B. Scherer and P.C. Weber, 1978, Time dependent changes in prostaglandin excretion in response to furosemide in man. Clin. Sci. 56:77–81.Google Scholar
  31. 31.
    B. Scherer and P.C. Weber, 1980, Urinary prostaglandins in the newborn: Relationship to urinary osmolality, urinary potassium, and blood pressure. In: Advances in prostaglandin and thromboxane research, Vol. 7, B. Samuelsson, P.W. Ramwell and R. Paoletti, edit., Raven Press, New York, pp.1033–1038.Google Scholar
  32. 32.
    B. Scherer and P.C. Weber, 1980, Renal factors in juvenile hypertension. Klin. Wschr. 58:1099–1104.PubMedCrossRefGoogle Scholar
  33. 33.
    J. Schnermann and P.C. Weber, 1980, A role of renal cortical prostaglandins in the control of glomerular filtration rate in rat kidneys. In: Advances in prostaglandin and thromboxane research, Vol. 7, B. Samuelsson, P.W. Ramwell and R. Paoletti edit., Raven Press, New York, pp. 1047–1052.Google Scholar
  34. 34.
    N.W. Schoene, V.B. Reeves and A. Ferretti, 1980, Effects of dietary linoleic acid on the biosynthesis of PGE2 and PGF in kidney medullae in spontaneously hypertensive rats. In: Advances in prostaglandin and thromboxane research, Vol.8, B. Samuelsson, P.W. Ramwell and R. Paoletti edit., Raven Press, New York, pp. 1791–1792.Google Scholar
  35. 35.
    Y. Shibouta, Y. Inada, Z. Terashita, K. Nishikawa, S. Kikuchi and K. Shimamoto, 1979, Angiotensin-II-stimulated release of thromboxane A2 and prostacyclin (PGI2) in isolated, perfused kidneys of spontaneously hypertensive rats. Biochem. Pharmacol. 28:3601–3609.PubMedCrossRefGoogle Scholar
  36. 36.
    W. Seiss, P. Roth, B. Scherer, I. Kurzmann, B. Böhlig and P.C. Weber, 1980, Platelet — membrane fatty acids, platelet aggregation, and thromboxane formation during a mackerel diet. The Lancet 1:441–444.CrossRefGoogle Scholar
  37. 37.
    L. Somova, P. Hoffmann and W. Förster, 1980, The reactivity of isolated blood vessels of salt-loaded rats fed with low or high linoleic acid diets. Europ. J. Pharmacol. 64:79–83.CrossRefGoogle Scholar
  38. 38.
    S.Y. Tan, P. Sweet and P.J. Mulrow, 1978, Impaired renal production of prostaglandin E2: A newly identificated lesion in human essential hypertension. Prostaglandins 15:139.PubMedCrossRefGoogle Scholar
  39. 39.
    M. Ulrych, 1976, The role of vascular capacitance in the genesis of essential hypertension. Clin. Sci. Mol. Med. 51: 203s-205s.Google Scholar
  40. 40.
    J.R. Vane, J.C. McGiff, 1975, Possible contributions of endogenous prostaglandins to the control of blood pressure. Circ. Res. 36 and.37, suppl. I, 1–68 and 1–75.Google Scholar
  41. 41.
    P.C. Weber, C. Larsson and B. Scherer, 1977, Prostaglandin E — 9-ketoreductase as a mediator of salt intake-related prostaglandin-renin interaction. Nature 266:65–66.CrossRefGoogle Scholar
  42. 42.
    P.C. Weber, B. Scherer and C. Larsson, 1977, Increase of free arachidonic acid by furosemide in man as the cause of prostaglandin and renin release. Europ. J. Pharmacol. 41: 392–332.CrossRefGoogle Scholar
  43. 43.
    P.C. Weber, B. Scherer, E. Held, W. Siess and H. Stoffel, 1979, Urinary prostaglandins and kallikrenin in essential hypertension. Cli. Sci. 57:295s-261s.Google Scholar
  44. 44.
    P.C. Weber, B. Scherer, W. Siess, E. Held and J. Schnermann, 1980, Possible significance of renal prostaglandins for renin release and blood pressure control. In: Advances in prostaglandin and thromboxane research, Vol. 7, B. Samuelsson, P.W. Ramwell and R. Paoletti edit., Raven Press, New York, pp. 1067–1077.Google Scholar
  45. 45.
    P.C. Weber, B. Scherer, W. Siess, E. Held and J. Schnermann, 1979, Formation and action of prostaglandins in the kidney. Klin. Wochenschr. 57:1021–1029.PubMedCrossRefGoogle Scholar
  46. 46.
    P.C. Weber, W. Siess and B. Scherer, 1979, Prostaglandins in cardiovascular and renal function: Biochemical, physiological and clinical findings. Klin. Wochenschr. 57:425–444.PubMedCrossRefGoogle Scholar
  47. 47.
    P.C. Weber, W. Siess and B. Scherer, 1980, Possible significance of renal prostaglandins in essential hypertension. Clin. and Expt. Hypertension 2:(3 and 4), 741–760.CrossRefGoogle Scholar
  48. 48.
    A. Wennmalm, 1978, Influence of indomethacin on the systemic and pulmonary vascular resistance in man. Clin. Sci. Mol. Med. 54:141–145.PubMedGoogle Scholar
  49. 49.
    R.M. Zusman, and H.R. Keiser, 1977, Prostaglandin E2 biosynthesis by rabbit renomedullary interstitial cells in tissue culture. J. Biol. Chem. 252:2069–2071.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • P. C. Weber
    • 1
  • B. Scherer
    • 1
  • W. Siess
    • 1
  1. 1.Medizinische Klinik Innenstadt8 München 2Germany

Personalised recommendations