Fibrinolytic Vessel Wall Activator in Arterial Thrombosis
The general consensus is that the fibrinolytic system is the main defence system against thrombo-embolism on the venous side, as illustrated in Fig. 1. This is reasonable because the venous thrombus is more or less a coagulation thrombus where fibrin is predominant, whereas on the arterial side the platelets are the dominant constituent. However, in a fully developed arterial thrombus there is after all some fibrin, the breakdown of which could lead to instabilization and thus halting further growth. It is even possible that the fibrinolytic system might be of importance in the early phase of thrombus formation, since forming fibrin may induce the platelet release reaction. As the fibrin in this stage is most susceptible to plasmin, and the vessel wall activator is stored very close to the initial events, it is feasible that an attack on the fibrin during formation would be of particular importance as a defence phenomenon. However, there has been very little attempt to devise models to pursue this possibility. So far, the evidence for a role of the fibrinolytic system in the defence against arterial thrombosis stems from observations on different patient-groups, and this evidence is steadily becoming stronger.
KeywordsFactor VIII Fibrinolytic Activity Arterial Thrombosis Fibrinolytic System Abstract Book
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