Prostacyclin and its Analogues for the Therapy of Thromboembolic Disorders

  • B. J. R. Whittle
  • S. Moncada
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 164)


The discovery that blood vessels synthesize and release an unstable arachidonic acid metabolite, prostacyclin, which is a potent vasodilator and inhibitor of platelet aggregation (Moncada, Gryglewski, Bunting and Vane, 1976) has implicated this prostanoid as an important factor in the regulation of vascular tone and haemostasis (Moncada and Vane, 1979). This bicyclic enol-ether is derived from the fatty acid precursor arachidonic acid via the unstable endoper-oxide intermediates. These are transformed by the action of an enzyme system, prostacyclin synthetase, which is located predominantly in vascular endothelium. It has become apparent that prostacyclin has many potential clinical applications for the management of thromboembolic disorders (Table 1).


Platelet Aggregation Thrombotic Thrombocytopenic Purpura Trisodium Citrate Haemolytic Uraemic Syndrome Prostacyclin Analogue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • B. J. R. Whittle
    • 1
  • S. Moncada
    • 1
  1. 1.Department of Prostaglandin ResearchLangley CourtBeckenham, KentUK

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