Pathophysiology of Arterial Thrombosis

  • E. F. Lüscher
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 164)


It is today an established fact that myocardial infarction in most cases is due to the obstruction by thrombi of the coronary vessels (5, 15, 2 as well as 3 for further references). Thus Bulkley and Hutchins (5) find, in 88% of all post-mortem examinations, in patients with aterosclerotic coronary artery disease, evidence for the existence of thrombi. Thus, arterial thrombosis is a major contributing factor to myocardial infarction and its pathophysiology therefore deserves every attention. Arterial thrombi as a rule start from a vascular lesion, most often from ruptured atheromas and have been shown to progress from a primary deposite of blood platelets. Thus, arterial thrombosis in many respects appears as the pathological deviation from a physiological process, i.e. the formation of a hemostatic plug. It appears appropriate to deal first with the mechanisms which are involved in the production of a platelet aggregate, which by its self, or by virtue of its procoagulant properties and subsequent fibrin formation, is capable of occluding a blood vessel.


Platelet Activation Coronary Thrombosis Arterial Thrombosis Blood Platelet Release Reaction 
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  1. 1.
    H.R. Baumgartrier, The subendothelial surface and thrombosis. In: Pathogenesis and clinical trials. Trans. IV Int. Congr. on Thrombosis and Haemostasis. E. Deutsch, K.M. Brinkhous, K. Lechner, S. Hinnom, Ed., Shattauer, Stuttgart, N.Y. (1974).Google Scholar
  2. 2.
    P.A. Bolhuis, K.S. Sakariassen, J.J. Sixma, Adhesion of blood platelets to human arterial subendothelium: Role of factor VIII — von Willebrand factor. Haemostasis 8:312–323 (1979).PubMedGoogle Scholar
  3. 3.
    G.V.R. Born, Die Rolle der Blutplättchen in der Pathogenese des Herzinfarktes. in.: “Neue Aspekte der medikamentösen Behandlung des Herzinfarktes”. F. Gross, ed., Huber, Bern Stuttg., Wien, S. 119–123 (1979).Google Scholar
  4. 4.
    G.C. Le Breton, R.J. Dinerstein, L.J. Roth, H. Feinberg, Direct evidence for intracellular divalent cation redistribution associated with platelet shape change. Biochem. Biophys. Res. Comm. 71:362–370 (1976).PubMedCrossRefGoogle Scholar
  5. 5.
    B.H. Bulkley, J.M. Hutchins, Coronary thrombosis: The major cause of acute myocardial infarction in atherosclerotic coronary artery disease. Circulation 56/11, 111–64 (1977).Google Scholar
  6. 6.
    J.W. Burch, P.W. Majerus, The role of prostaglandins in platelet function. Sem. Hemat. 16:196–207 (1979).Google Scholar
  7. 7.
    M. Chignard, J.P. le Couedic, M. Tence, B.B. Vargaftig, J. Benveniste, The role of platelet-activating factor in platelet aggregation. Nature, Lond. 279:799–800 (1979).CrossRefGoogle Scholar
  8. 8.
    J.M. Gerrard, A.M. Butler, G. Graff, S.F. Stoddard, J.G. White, Prostaglandin endoperoxides promote calcium release from a platelet membrane preparation. Prostaglandins Med. 1:373–385 (1978).PubMedCrossRefGoogle Scholar
  9. 9.
    R. Käser-Glanzmann, M. Jakábová, N.J. George, E.F. Luscher, Stimulation of calcium uptake in platelet membrane vesicles by adenosine 3, 5′ cyclic monophosphate and protein kinase. Biochim. Biophys. Acta 466:429–440 (1977).PubMedCrossRefGoogle Scholar
  10. 10.
    P. Latimer, G.V.R. Born, F. Michal, Application of light-scattering theory to the optical effects associated with the morphology of blood platelets. Arch. Biochem. Biophys. 180: 151–159 (1977).PubMedCrossRefGoogle Scholar
  11. 11.
    G.A. Marguerie, T.S. Edgington, E.F. Plow, Interaction of fibrinogen with its platelet receptor as part of a multistep reaction in ADP-induced platelet aggregation. J. Biol. Chem. 255:154–161 (1980).PubMedGoogle Scholar
  12. 12.
    P. Massini, E.F. Lüscher, Some effects of ionophores for divalent cations on blood platelets — comparison with the effects of thrombin. Biochim. Biophys. Acta 372:109–121 (1974).PubMedCrossRefGoogle Scholar
  13. 13.
    P. Massini, E.F. Lüscher, On the significance of the influx of calcium ions into stimulated human blood platelets. Biochim. Biophys. Acta 436:652–663 (1976).PubMedCrossRefGoogle Scholar
  14. 14.
    E. Morgenstern, Ultracytochemistry of human blood platelets. Progr. Histochem. Cytochem. 12, 4 (1980).Google Scholar
  15. 15.
    R. Okada, T. Konoh, A morphological study on relationship between coronary thrombosis and myocardial infarction. Blood and Vessel 9:510–515 (1978).CrossRefGoogle Scholar
  16. 16.
    D.S. Pepper, Macromolecules released from platelet storage organelles. Thrombos. Haemostas. 42:1667–1672 (1979).Google Scholar
  17. 17.
    D.R. Phillips, An evaluation of membrane glyciproteins in platelet adhesion and aggregation. Progr in Thrombosis and Haemostasis 5:81–108 (1980).Google Scholar
  18. 18.
    P.N. Walsh, Platelet coagulant activities: Evidence for multiple, different function of platelets in intrinsic coagulation. Ser. Haemat. 6:579–592 (1973).Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • E. F. Lüscher
    • 1
  1. 1.Theodor Kocher InstituteUniversity of BerneBerneSwitzerland

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