Advertisement

Platelet Function Changes in Acute Myocardial Infarction

  • G. Davì
  • M. Traina
  • S. Novo
  • V. Albano
  • G. L. Piraino
  • M. P. Muzzo
  • G. Marano
  • A. Raineri
  • A. Strano
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 164)

Abstract

Whether the thrombotic component of myocardial infarction is primary or secondary in a given patient, platelet function alterations can influence many mechanisms — operating at the microenvi-ronmental level — from which it depends if the thrombotic lesion grows or sends platelet emboli to the smaller myocardial vessels.

Keywords

Acute Myocardial Infarction Platelet Aggregation Platelet Function Platelet Sensitivity Spontaneous Platelet Aggregation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    S.C. Sharma, H.N. Setn, Platelet adhesiveness, plasma fibrinogen and fibrinolytic activity in acute myocardial infarction. Brit. Heart J. 40:526 (1978).PubMedCrossRefGoogle Scholar
  2. 2.
    J. Gormsen, J.B. Knudsen, J.D. Nielsen, O. Amtorp, K. Skagen, Platelet function, coagulation, fibrinolysis, factor XIII and antithrombin III in acute transmural myocardial infarction. In: Proc. of Florence Int. Meet. on Myoc. Inf., May 8–12, 1979, p.233, Excerpta Medica, Amsterdam-Oxford-Princeton (1979).Google Scholar
  3. 3.
    P. Mehta, J. Mehta, Platelet function studies in coronary artery disease. V. Evidence for enhanced platelet micro-thrombus formation activity in acute myocardial infarction. Am. J. Cardiol. 43:757 (1979).PubMedCrossRefGoogle Scholar
  4. 4.
    P. Steele, J. Rainwater, R. Vogel, Abnormal platelet survival time in men with myocardial infarction and normal coronary arteriogram. Am. J. Cardiol. 41:60 (1978).PubMedCrossRefGoogle Scholar
  5. 5.
    K. Gjesdal, Platelet function and plasma free fatty acids during acute myocardial infarction and severe angina pectoris. Scand. J. Haematol. 17:205 (1976).PubMedCrossRefGoogle Scholar
  6. 6.
    R.I. Handin, M. McDonough, M. Lesch, Evaluation of platelet factor four in acute myocardial infarction. Measurement by radioimmunoassay. J. Lab. Clin. Med. 91:340 (1978).PubMedGoogle Scholar
  7. 7.
    H.H. Salem, J. Koutts, B.G. Firkin, Circulating platelet aggregates in ischaemic heart disease and their correlation to platelet life span. Thromb. Res. 17:707 (1980).PubMedCrossRefGoogle Scholar
  8. 8.
    J. Zahavi, The role of platelets in myocardial infarction, ischemic heart disease, cerebrovascular disease, thromboembolic disorders and acute idiopathic pericarditis. Thromb. Haemostas. 38:1073 (1977).Google Scholar
  9. 9.
    M. Packham, Methods for detection of hypersensitive platelets. Thromb. Haemost. 40:175 (1978).PubMedGoogle Scholar
  10. 10.
    V. Rasi, T. Torstila, E. Ikkala, Beta-thromboglobulin in acute myocardial infarction . Acta Med. Scand. (SuppL) 642:85 (1980).Google Scholar
  11. 11.
    A. Szczeklik, M. Serwonska, W. Lukasiewicz, J. Mruk, J. Musial, Arachidonate versus ADP-induced platelet aggregation in acute myocardial infarction. Thrombos.Haemostas. 42:822 (1979).Google Scholar
  12. 12.
    E. Granström, H. Kindhai, B. Samuelsson, Radioimmunoassay for thromboxane B2. Analyt. Letters 9;611 (1976).CrossRefGoogle Scholar
  13. 13.
    K.K. Wu, J.C. Hoak, Spontaneous platelet aggregation in arterial insufficiency: mechanisms and implications. Thrombos. Haemostas. 35:702 (1976).Google Scholar
  14. 14.
    P. Mehta, J. Mehta, Platelet function studies in coronary heart disease: VIII. Decreased platelet sensitivity to prostacyclin in patients with myocardial ischaemia. Thromb. Res. 18:273 (1980).PubMedCrossRefGoogle Scholar
  15. 15.
    J.R. O’Brien, M.D. Etherington, R.D. Shuttleworth, Ticlopidine — an antiplatelet drug: effects in human volunteers. Thromb. Res. 13:245 (1978).PubMedCrossRefGoogle Scholar
  16. 16.
    J. Valles, J. Aznar, M.T. Santos, Platelet fatty acids in acute myocardial infarction. Thromb. Res. 14:231 (1979).PubMedCrossRefGoogle Scholar
  17. 17.
    E. Marcinkiewicz, L. Grodzinska, R.J. Gryglewski, Platelet aggregation and thromboxane A2 generation in platelet rich plasma. Pharmacol. Res. Commun. 10:1 (1978).PubMedCrossRefGoogle Scholar
  18. 18.
    A. Szczeklik, R.J. Gryglewski, J. Musial, L. Grodzinska, M. Serwonska, E. Marcinkiewicz, Thromboxane generation and platelet aggregation in survivals of myocardial infarction. Thromb. Haemostas. 40:66 (1978).Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • G. Davì
    • 1
  • M. Traina
    • 2
  • S. Novo
    • 1
  • V. Albano
    • 3
  • G. L. Piraino
    • 2
  • M. P. Muzzo
    • 1
  • G. Marano
    • 1
  • A. Raineri
    • 2
  • A. Strano
    • 1
  1. 1.Institute of Clinical Medicine and Medical TherapyUniversity of PalermoPalermoItaly
  2. 2.Institute of Cardiovascular PhysiopathologyUniversity of PalermoPalermoItaly
  3. 3.Institute of Pharmacology “R”University of PalermoPalermoItaly

Personalised recommendations