Methods for the Detection of Activated Platelets

  • F. I. Pareti
  • A. D’Angelo
  • P. M. Mannucci
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 164)


There is substantial evidence that blood platelets may play an important role in the development and progression of premature atherosclerotic disease and its complications. (Mustard and Packham 1975, Ross and Glomset 1976 and Harker et al. 1976). It has been demonstrated that platelet function, as measured by a variety of different in vitro methods, is often increased in patients with atherosclerosis and related conditions predisposing to or associated with premature atherosclerosis. However, it is still not known whether the abnormalities of platelet function are primary, that is are induced by changes in the blood associated with the atherosclerosis risk factors or are consequences of the vascular injury, that initiates platelet adherence, followed by the release from platelets of substances that can cause vascular injury and promote the growth of smooth muscle cells and fibroblasts (Mustard and Packham 1975, Harker et al. 1976). The latter hypothesis, assuming that the primary feature in arterial disease is probably damage of the vessel wall rather than hyperreactivity of blood platelets is the commonly favored one.


Platelet Aggregation Angina Pectoris Peripheral Arterial Disease Platelet Function Thrombotic Thrombocytopenic Purpura 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • F. I. Pareti
    • 1
  • A. D’Angelo
    • 1
  • P. M. Mannucci
    • 1
  1. 1.Centro Angelo Bianchi Bonomi per la Cura delle Malattie Emorragiche, Istituto di Clinica Medica IIIUniversità degli Studi di MilanoItaly

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