Abstract
Platelets are essentially involved in primary hemostasis. During the first seconds after a vascular lesion they are stimulated on the damaged vessel wall as well as inside and outside of the vessel. Many of today’s concepts on the mechanism of primary hemostasis and also on the first steps in thrombus formation have been derived from aggregometer studies. But it has to be kept in mind that induced or spontaneous aggregation, as they are usually studied in vitro, only occur if the platelets are partially or totally shape changed, have become more adhesive and tend to aggregate much more than the circulating disc-like platelets.
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© 1984 Plenum Press, New York
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Breddin, K., Bender, N., Kirchmaier, C.M. (1984). On the Mechanism of Platelet Activation During Hemostasis and Thrombosis and on the Effects of Platelet Inhibiting Drugs. In: Strano, A. (eds) Thrombosis and Cardiovascular Disease. Advances in Experimental Medicine and Biology, vol 164. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8616-2_15
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DOI: https://doi.org/10.1007/978-1-4684-8616-2_15
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