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On the Mechanism of Platelet Activation During Hemostasis and Thrombosis and on the Effects of Platelet Inhibiting Drugs

  • K. Breddin
  • N. Bender
  • C. M. Kirchmaier
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 164)

Abstract

Platelets are essentially involved in primary hemostasis. During the first seconds after a vascular lesion they are stimulated on the damaged vessel wall as well as inside and outside of the vessel. Many of today’s concepts on the mechanism of primary hemostasis and also on the first steps in thrombus formation have been derived from aggregometer studies. But it has to be kept in mind that induced or spontaneous aggregation, as they are usually studied in vitro, only occur if the platelets are partially or totally shape changed, have become more adhesive and tend to aggregate much more than the circulating disc-like platelets.

Keywords

Platelet Aggregation Platelet Activation Primary Hemostasis Spontaneous Aggregation Anti Thrombotic Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • K. Breddin
    • 1
  • N. Bender
    • 1
  • C. M. Kirchmaier
    • 1
  1. 1.Department of Internal MedicineJ.W. Goethe UniversityD-Frankfurt a.M.Germany

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