Blood Viscosity and the Complications of Diabetes
Increased viscosity in diabetes mellitus was forst noted by Skovborg et al. (1966) and has since been confirmed by several groups including Isogai et al. (1976) and Barnes et al. (1977) although the results are somewhat conflicting. These studies have mostly been carried out in older diabetics in whom the presence of atherosclerosis may cause secondary changes or mask understanding of the underlying haemostatic abnormalities. It is important also to take into account the variable clinical features such as smoking, renal impairment or diabetic retinopathy. We have taken the opportunity to study a homogeneous group of younger insulin treated male diabetics and compared them with an age and smoking matched control group of normal people. The main measurements included haematocrit, plasma fibrinogen (measured by the Clauss technique), plasma viscosity (measured by BS M3 capillary viscometer), and whole blood viscosity at a high (100s-l) and low shear rate (0.94s-1) in a rhombo-spheroid rotational viscometer. The low shear rate studies were measured in a Contraves Model LS 30 viscometer.
KeywordsDiabetic Retinopathy Vascular Complication Blood Viscosity High Shear Rate Plasma Fibrinogen
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- Lowe, G.D.O., Signorello, M., Parker, J.L.S., Manderson, W.G., Forbes, C.D., and Prentice, C.R.M., 1980, Platelet aggregates and plasma fibrinogen in diabetes. Microvascular Research 20, 259 (Abstract).Google Scholar