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Translational Control of Gene Expression in E. Coli and Bacteriophage

  • Mathias Springer

Abstract

Gene expression can be regulated in response to very different stimuli. These may be external, such as the cellular growth medium, or internal, in response to a specific need at a given stage of the cell cycle or development. In many cases, the regulation is transcriptional. The discovery that translation is a level of gene expression at which regulation can take place goes back to the observation that transcription is not necessary for early phases of embryonic development in many organisms.1 Gene expression following fertilization relies completely on maternal mRNAs which are translationally repressed until then.2 Translational control in prokaryotes was discovered first with RNA bacteriophages where translation is the sole possible level of regulation,3,4 later in DNA phages and finally in E. coli. Even if much remains to be understood about translational regulation in this bacterium, very few genes from other prokaryotes or from eukaryotes have been studied in the same kind of molecular detail as those of coliphages and E. coli itself.

Keywords

Ribosomal Protein Coat Protein Translational Control Translational Operator Initiator tRNA 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© R.G. Landes Company 1996

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  • Mathias Springer

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