Roles for Energy-Dependent Proteases in Regulatory Cascades

  • Susan Gottesman


In theory, the rapid degradation of a protein may play as critical a role in regulating protein activity as controls on transcription and translation. However, the role of protein turnover in regulation received relatively little attention during the years when the elegant systems for regulation of transcription initiation were first being investigated. The first dramatic example of a proteolytic event with clear regulatory consequences was provided by the demonstration, in 1975, that induction of bacteriophage lambda after DNA damage was due to cleavage of the lambda repressor.1 Since those experiments, an increasing number of proteases and interesting protein targets have been identified, both in prokaryotes and eukaryotes.


Abnormal Protein Regulatory Cascade Unstable Protein Prophage Induction Capsule Synthesis 
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  • Susan Gottesman

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