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Heat Shock Regulation

  • Dominique Missiakas
  • Satish Raina
  • Costa Georgopoulos

Abstract

The heat shock or stress response of Escherichia coli has evolved in order to detect and deal with the presence of unfolded, misfolded, damaged or aggregated polypeptide chains. At the present, two major regulons are known to control this response. The “classical” heat shock regulon has evolved to deal with intracellular protein perturbations and is under the positive control of the σ32 transcription factor (the rpoH gene product) and the negative control of some of the heat shock proteins themselves. The newly discovered second heat shock regulon has evolved to deal with protein misfolding/aggregation/imbalance in the outer cellular compartments. It is under the positive control of the σE transcription factor (the rpoE gene product). The two heat shock regulons appear to be interconnected, inasmuch as the σE factor participates in the transcriptional regulation of the σ32-encoding gene, especially at very high temperatures.

Keywords

Heat Shock Heat Shock Protein Sigma Factor Heat Shock Response Heat Shock Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© R.G. Landes Company 1996

Authors and Affiliations

  • Dominique Missiakas
  • Satish Raina
  • Costa Georgopoulos

There are no affiliations available

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