Characterization of Commercial Formulations by Combining Several Chromatographic Techniques with Multiple-Internal-Reflection and Mass Spectrometry
Analytical chemists are frequently confronted with the problem of characterizing complex mixtures of compounds. The complex mixtures that are characterized and discussed in this paper are diverse commercial formulations. Although several approaches can be employed for the characterization of these formulations, this paper discusses one which we have found to be convenient and reliable. In this approach liquid—solid partition, thin—layer, and gas—liquid chromatography are employed to isolate and identify the components in a mixture, and multiple-internal-reflection and mass spectroscopy are employed to identify or confirm the identity of the components. This approach has been successfully employed to solve problems in our laboratories for several years. The advantages, disadvantages, and limitations of this approach are discussed in detail.
KeywordsElectron Spin Resonance Commercial Formulation Methyl Alcohol Fraction Collector Chromogenic Reagent
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