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Characterization of Commercial Formulations by Combining Several Chromatographic Techniques with Multiple-Internal-Reflection and Mass Spectrometry

  • T. S. Hermann
  • R. L. Levy
  • L. J. Leng
  • A. A. Post
Part of the Developments in Applied Spectroscopy book series (DAIS, volume 7b)

Abstract

Analytical chemists are frequently confronted with the problem of characterizing complex mixtures of compounds. The complex mixtures that are characterized and discussed in this paper are diverse commercial formulations. Although several approaches can be employed for the characterization of these formulations, this paper discusses one which we have found to be convenient and reliable. In this approach liquid—solid partition, thin—layer, and gas—liquid chromatography are employed to isolate and identify the components in a mixture, and multiple-internal-reflection and mass spectroscopy are employed to identify or confirm the identity of the components. This approach has been successfully employed to solve problems in our laboratories for several years. The advantages, disadvantages, and limitations of this approach are discussed in detail.

Keywords

Electron Spin Resonance Commercial Formulation Methyl Alcohol Fraction Collector Chromogenic Reagent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Reference

  1. 1.
    R.P.W. Scott, I.A. Fowlis, D. Welti, and T. Wilkins in Gas Chromatography 1966, A.B. Littlewood (ed.), Elsevier, New York (1967), pp. 318–333.Google Scholar

Copyright information

© Chicago Section of the Society for Applied Spectroscopy 1970

Authors and Affiliations

  • T. S. Hermann
    • 1
  • R. L. Levy
    • 1
  • L. J. Leng
    • 1
  • A. A. Post
    • 1
  1. 1.Midwest Research InstituteKansas CityUSA

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