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Human Placental Adenosine Kinase: Purification and Characterization

  • Catherine M. Andres
  • Thomas D. Palella
  • Irving H. Fox
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 122B)

Abstract

The regulation of adenosine metabolism is an important factor in the determination of the biological properties of this compoundl. Although the deamination of adenosine has been carefully characterized, only a limited amount of information is available concerning its phosphorylation in mammalian tissue. We have undertaken the purification and characterization of human placental adenosine kinase (E. C.2.7.1.20), which catalyzes the reaction:
$$Adenosine + ATP \to AMP + ADP$$

Keywords

DEAE Cellulose Adenosine Kinase Subunit Molecular Weight USPHS Grant Stokes Radius 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    I. H. Fox and W. N. Kelley, The role of adenosine and deoxyadenosine in mammalian cells, Ann. Rev. Biochem. 47:655 (1978).PubMedCrossRefGoogle Scholar
  2. 2.
    C.M. Andres and I. H. Fox, The phosphorylation of adenosine and deoxyadenosine using purified adenosine kinase, Clin. Res. 26:671A (1978).Google Scholar
  3. 3.
    C.M. Andres and I. H. Fox, Purification and properties of human placental adenosine kinase, (In Preparation).Google Scholar
  4. 4.
    T. D. Palella, C. M. Andres, and I. H. Fox, Regulation of human placental adenosine kinase, Fed. Proc. 38:669 (1979).Google Scholar
  5. 5.
    T. D. Palella, C. M. Andres, and I. H. Fox, Regulation of human placental adenosine kinase, (In Preparation).Google Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Catherine M. Andres
    • 1
  • Thomas D. Palella
    • 1
  • Irving H. Fox
    • 1
  1. 1.Human Purine Research Center Departments of Internal Medicine and Biological ChemistryUniversity of MichiganAnn ArborUSA

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