Xanthine Oxidoreductase Inhibition by NADH as a Regulatory Factor of Purine Metabolism
Xanthine oxidoreductase occurs in mammalian tissues mostly in a NAD+-dependent form1. In rat liver this dehydrogenase form accounts for over 85 % of total enzyme, the rest being an intermediate dehydrogenase-oxidase form which preferably reacts with NAD% but can also use O2as an electron acceptor2. Both these forms are inhibited by NADH2, in contrast to the O2-dependent form3 arising from them2.
KeywordsUric Acid Salvage Pathway Dehydrogenase Form Dependent Form Xanthine Oxidoreductase
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