Micromethods for the Measurement of Purine Enzymes in Lymphocytes
The involvement of purine interconversion enzyme defects in impairment of the immune system is now well documented (1–3). Although it has been suggested that deoxypurine nucleotides might be the toxic metabolites in these immune diseases (4–5), the mechanism which leads to dysfunctions of T or B cells, or both of them, is still not completely elucidated. A better understanding of purine interconversions in B and T cell subfractions might help to obtain a better view on B or T cell specificity in these immune diseases. One of the possibilities to achieve this might be a systematic analysis of purine metabolism in T and non-T lymphocytes.
KeywordsPurine Metabolism Immune Disease Purine Nucleoside Phosphorylase Disodium EDTA Adenine Phosphoribosyltransferase
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