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Biochemical Consequences of Treatment with the Adenosine Deaminase Inhibitor 2′-Deoxycoformycin

  • Rosanne M. Paine
  • J. F. Smyth
  • K. R. Harrap
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 122B)

Abstract

A congenital absence of the enzyme adenosine deaminase (ADA, EC 3.5.4.4) has been associated with profound T and B cell deficiencies in children, leading to immune dysfunction (1). Cohen et al (2) have demonstrated that ADA deficient children have elevated levels of 2′-deoxyadenosine triphosphate (dATP) in their erythrocytes. dATP is a known negative effector of the enzyme ribonucleotide reductase (3). In view of the finding that ADA activity is high in the blast cells of patients with T-cell acute lymphocytic leukaemia (4), an ADA inhibitor might well induce a selectively toxic event in the lymphoblast.

Keywords

Adenosine Deaminase Adenosine Deaminase Activity Triplicate Assay Adenosine Deaminase Deficiency Deoxyadenosine Triphosphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Rosanne M. Paine
    • 1
  • J. F. Smyth
    • 1
  • K. R. Harrap
    • 1
  1. 1.Institute of Cancer ResearchSutton, SurreyEngland

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