Treatment of Acute Lymphoblastic Leukemia with the Adenosine Deaminase Inhibitor 2′-Deoxycoformycin
Part of the
Advances in Experimental Medicine and Biology
book series (AEMB, volume 122B)
Congenital deficiency of the enzyme adenosine deaminase (ADA, EC 220.127.116.11.) is associated with severe combined immunodeficiency disease characterized by marked lymphopenia and thymic involution.1 ADA catalyzes the deamination of adenosine and deoxyadenosine to inosine and deoxyinosine, respectively, and it has been proposed that the increased levels of deoxyadenosine associated with ADA deficiency lead to the selective accumulation of dATP by lymphoid cells, inhibition of DNA synthesis and cell death.2
KeywordsAcute Lymphoblastic Leukemia Adenosine Deaminase Thymic Involution Severe Combine Immunodeficiency Disease Adenosine Concentration
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
E. R. Giblett, J. E. Anderson, F. Cohen, B. Pollara, and H. J. Meuwissen, Adenosine deaminase deficiency in two patients with severely impaired cellular immunity Lancet
2:1067 (1972).PubMedCrossRefGoogle Scholar
D. A. Carson, J. Kaye and J. E. Seegmiller, Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside Phosphorylase deficiency: possible role of nucleoside kinase(s). Proc. Natl. Acad. Sci. U.S.A.
74:5677 (1977).PubMedCrossRefGoogle Scholar
B. S. Mitchell, E. Mejias, P. E. Daddona, and W. N. Kelley, Purinogenic immunodeficiency diseases: selective toxicity of deoxyribonucleosides for T cells. Proc. Natl. Acad. Sci. U.S.A.
75:5011 (1978).PubMedCrossRefGoogle Scholar
D. A. Cason, J. Kaye, and J. E. Seegmiller, Differential sensitivity of human leukemic T cell lines and B cell lines to growth inhibition by deoxyadenosine. J. Immunol.
121:1726 (1978).Google Scholar
R. P. Agarwal, T. Spector, and R. E. Parks, Tight-binding inhibitors — IV. Inhibition of adenosine deaminase by various inhibitors. Biochem. Pharm.
26:359 (1977).PubMedCrossRefGoogle Scholar
© Plenum Press, New York 1980