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Treatment of Acute Lymphoblastic Leukemia with the Adenosine Deaminase Inhibitor 2′-Deoxycoformycin

  • Beverly S. Mitchell
  • Charles A. Koller
  • William N. Kelley
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 122B)

Abstract

Congenital deficiency of the enzyme adenosine deaminase (ADA, EC 3.5.4.4.) is associated with severe combined immunodeficiency disease characterized by marked lymphopenia and thymic involution.1 ADA catalyzes the deamination of adenosine and deoxyadenosine to inosine and deoxyinosine, respectively, and it has been proposed that the increased levels of deoxyadenosine associated with ADA deficiency lead to the selective accumulation of dATP by lymphoid cells, inhibition of DNA synthesis and cell death.2

Keywords

Acute Lymphoblastic Leukemia Adenosine Deaminase Thymic Involution Severe Combine Immunodeficiency Disease Adenosine Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    D. A. Carson, J. Kaye and J. E. Seegmiller, Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside Phosphorylase deficiency: possible role of nucleoside kinase(s). Proc. Natl. Acad. Sci. U.S.A. 74:5677 (1977).PubMedCrossRefGoogle Scholar
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    D. A. Cason, J. Kaye, and J. E. Seegmiller, Differential sensitivity of human leukemic T cell lines and B cell lines to growth inhibition by deoxyadenosine. J. Immunol. 121:1726 (1978).Google Scholar
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    R. P. Agarwal, T. Spector, and R. E. Parks, Tight-binding inhibitors — IV. Inhibition of adenosine deaminase by various inhibitors. Biochem. Pharm. 26:359 (1977).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Beverly S. Mitchell
    • 1
  • Charles A. Koller
    • 1
  • William N. Kelley
    • 1
  1. 1.Departments of Internal Medicine and Biological Chemistry, Human Purine Research CenterUniversity of Michigan Medical SchoolAnn ArborUSA

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