Adenosine Deaminase and Purine Nucleoside Phosphorylase in Acute and Chronic Lymphatic Leukemia
Significant progress in the classification of leukemia has been achieved by the introduction of methods which make detailled characterisation of cell membrane antigens or receptors possible (1). These methods have proved to be of considerable clinical relevance as tools for precise classification of the underlying leukemic process, thus providing more concise evaluation of prognosis and often serving as valuable guide for therapy. However, by these techniques the biochemical properties inherent in the individual leukemic cell clone cannot be analysed. These biochemical characteristics of neoplastic cells are the prerequisits for better understanding of the leukemic process and may furthermore be used in the development of new cytostatic agents and the establishment of new chemo therapeutical schemes (2). In addition, the analysis of the metabolism of leukemic cells might possibly allow prediction of sensitivity or resistance of the individual leukemic clone to certain cytostatic agents.
KeywordsAdenosine Deaminase Sheep Erythrocyte Purine Nucleoside Phosphorylase Cytostatic Agent Chronic Lymphatic Leukemia
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