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Adenosine Deaminase and Purine Nucleoside Phosphorylase in Acute and Chronic Lymphatic Leukemia

  • Heinz Ludwig
  • Heide Winterleitner
  • Rudolf Kuzmits
  • Mathias M. Müller
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 122B)

Abstract

Significant progress in the classification of leukemia has been achieved by the introduction of methods which make detailled characterisation of cell membrane antigens or receptors possible (1). These methods have proved to be of considerable clinical relevance as tools for precise classification of the underlying leukemic process, thus providing more concise evaluation of prognosis and often serving as valuable guide for therapy. However, by these techniques the biochemical properties inherent in the individual leukemic cell clone cannot be analysed. These biochemical characteristics of neoplastic cells are the prerequisits for better understanding of the leukemic process and may furthermore be used in the development of new cytostatic agents and the establishment of new chemo therapeutical schemes (2). In addition, the analysis of the metabolism of leukemic cells might possibly allow prediction of sensitivity or resistance of the individual leukemic clone to certain cytostatic agents.

Keywords

Adenosine Deaminase Sheep Erythrocyte Purine Nucleoside Phosphorylase Cytostatic Agent Chronic Lymphatic Leukemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Literatur

  1. 1.
    Koziner B., Filippa DA, Mertelamann R., Gupta S., Clarkson B., Good RA, Siegal FP: Characterization of the malignant lymphomas in leukemic phase by multiple differentiation markers of mononuclear cells. Am.J.Med. 63, 556, 1977.PubMedCrossRefGoogle Scholar
  2. 2.
    Scholar EM, Calabresi P.: Identification of the enzymatic pathways of nucleotide metabolism in human lymphocytes and leukemia cells. Cancer Res. 33, 94, 1973.PubMedGoogle Scholar
  3. 3.
    Allison AC, Hovi T., Watts RWE., Webster ADB.: The role of de novo-purine synthesis in lymphocyte transformation. In: Purine and Pyrimidine Metabolism. Ciba Foundation Symposium 48 pp 207, Elsevier, Exerpta Medica-North Holland. Amsterdam (1977).Google Scholar
  4. 4.
    Tsukimot’o I., Wong KY., Lampkin BC.: Surface markers and prognostic factors in acute lymphoblastic leukemia. N.Engl. J.Med. 294, 245 (1976)Google Scholar
  5. 5.
    Uitendaal MP., De Bruyn CHMM., Oei TL., Hösli P.: Ultramicrochemical studies on enzyme kinetics. Adv.Exp.Med.Biol. 76A, 597 (1977)PubMedGoogle Scholar
  6. 6.
    Uitendaal MP., De Bruyn, CHMM., Oei TL., Hösli P.: Characterisation of purine nucleoside Phosphorylase from fibroblast using ultra-micro-chemical methods. Human Heredity 28, 151 (1978)PubMedCrossRefGoogle Scholar
  7. 7.
    Ramot B., Brok-Simoni F., Barnea N., Bank I., Holtzmann F.: Adenosine deaminase (ADA) activity in lymphocytes of normal individuals and patients with chronic lymphatic leukemia. British Journal of Haematology 36, 66 (1977).CrossRefGoogle Scholar
  8. 8.
    Tung R., Silber R., Quagliata R., Conklyn M., Gottesman J., Hirschhorn R.: Adenosine deaminase activity in chronic lymphatic leukemia. Journal of Clinical Investigation 57, 756 (1976).PubMedCrossRefGoogle Scholar
  9. 9.
    Zimmer J., Khalifa AS., Lightbody JJ.: Decreased adenosine deaminase activity in acute lymphocytic leukemic children and their parents. Cancer Res.35, 68 (1975)PubMedGoogle Scholar
  10. 10.
    Smyth JF., Poplack DG., Holiman BJ., Leventhal BG.: Correlation of adenosine deaminase activity with cell surface markers in acute lymphoblastic leukemia. J.Clin.Invest. 710, 1978Google Scholar
  11. 11.
    Symth JF., Harrap KR: Adenosine deaminase activity in leukemia. Br.J.Cancer 31, 544 (1975)CrossRefGoogle Scholar
  12. 12.
    Sullivan JL., Osborne WRA., Wedgwood RJ.: Adenosine activity in lymphocytes. Brit.J.Haematol. 38, 15 (1978)CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Heinz Ludwig
    • 1
    • 2
  • Heide Winterleitner
    • 1
    • 2
  • Rudolf Kuzmits
    • 1
    • 2
  • Mathias M. Müller
    • 1
    • 2
  1. 1.Department of Internal Medicine II and Institute of Medical ChemistryUniversity of ViennaViennaAustria
  2. 2.St. Anna-Children-HospitalViennaAustria

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