Immunological Studies on Lesch-Nyhan Patients
Minor abnormalities of B-lymphocyte function have been reported in association with the Lesch-Nyhan (LN) syndrome (1). Other authors have not been able to confirm this (2,3). LN patients are not more susceptible to infections than healthy control individuals and no clinical evidence for impaired immune competence is available. Therefore, the immunological abnormalities, if present at all, might be rather marginal. In studies on phytohaemagglutinin (PHA) stimulated lymphocytes from one LN patient we observed a severely depressed lymphocytic proliferative response under certain in vitro conditions. This prompted us to further investigate several immunological parameters in three LN patients.
KeywordsHealthy Control Individual Pokeweed Mitogen Staphylococcal Protein Adenine Phosphoribosyltransferase Immunological Challenge
Unable to display preview. Download preview PDF.
- 3.E.W. Gelfland, I.H. Fox, M. Stuckey and H.M. Dosch, Clin. Exp. Immunol. 31:205 (1978).Google Scholar
- 5.Ph. Gausset, E.Vamos, S. Kulakowski, J. Duchateau, C. de Bruyn and G. Delespesse, ms. in preparation.Google Scholar
- 10.Ph. Gausset, J. Duchateau, H. Collit and G. Delespesse, ms. in preparation.Google Scholar
- 12.J.P.R.M. van Laarhoven, G.Th. Spierenburg, F.T.J.J. Oerlemans and C.H.M.M. de Bruyn, Adv. Exp. Med. Biol., this volume.Google Scholar