Immunological Studies on Lesch-Nyhan Patients

  • C. de Bruyn
  • Ph. Gausset
  • J. Duchateau
  • E. Vamos
  • S. Kulakowski
  • G. Delespesse
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 122B)


Minor abnormalities of B-lymphocyte function have been reported in association with the Lesch-Nyhan (LN) syndrome (1). Other authors have not been able to confirm this (2,3). LN patients are not more susceptible to infections than healthy control individuals and no clinical evidence for impaired immune competence is available. Therefore, the immunological abnormalities, if present at all, might be rather marginal. In studies on phytohaemagglutinin (PHA) stimulated lymphocytes from one LN patient we observed a severely depressed lymphocytic proliferative response under certain in vitro conditions. This prompted us to further investigate several immunological parameters in three LN patients.


Healthy Control Individual Pokeweed Mitogen Staphylococcal Protein Adenine Phosphoribosyltransferase Immunological Challenge 
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • C. de Bruyn
    • 1
  • Ph. Gausset
    • 2
  • J. Duchateau
    • 2
  • E. Vamos
    • 2
  • S. Kulakowski
    • 3
  • G. Delespesse
    • 2
  1. 1.Department of Human Genetics, Faculty of MedicineUniversity of NijmegenNijmegenThe Netherlands
  2. 2.Laboratory of Immunology and BloodtransfusionUniversity Hospital “St. Pierre”BrusselsBelgium
  3. 3.Institute “Les Petites Abeilles”VlezenbeekBelgium

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